Modern management of ocular surface squamous neoplasia

Abstract

Ocular surface squamous neoplasia (OSSN) consists of a wide range of conjuctival and corneal lesions ranging from dysplastic lesions to invasive squamous cell carcinoma. A number of risk factors, including genetic predisposition, immunosuppression, HPV infection, ultraviolet exposure and smoking, have been associated with the appearance of OSSN. The authors discuss the recent advances in the management of OSSN, and describe surgical techniques and medical approaches to treat this disease. The authors believe that ultra-high-resolution optical coherence tomography will provide invaluable help in the diagnosis of surface lesions and their recurrences in the near future.

Keywords::

• IFN-α_2b
• mitomycin C
• no-touch surgical excision
• ocular surface squamous neoplasia
• ultra-high-resolution optical coherence tomography

Financial & competing interests disclosure

The authors were supported in part by the National Institutes of Health Center core grant (P30EY014801), Research to Prevent Blindness Medical Student Fellowship, Department of Defence grant (W81XWH-09-1-0675), The Ronald and Alicia Lepke grant, The Jimmy and Gay Bryan grant, and the Lee and Claire Hager grant. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.