Targeting neovascularization in ischemic retinopathy: recent advances

Mohamed Al-Shabrawey Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA. [email protected]; Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt; Vascular Biology Center, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, GRU, Augusta, GA, USA

Mohamed Elsherbiny Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA; Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt

Julian Nussbaum Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA

Amira Othman Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt; Department of Anatomy, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Daqahlia, Egypt

Sylvia Megyerdi Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA; Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA

Amany Tawfik Ophthalmology and Vision Discovery Institute, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, GRU, Augusta, GA, USA; Department of Oral Biology/Anatomy, College of Dental Medicine, Georgia Regents University (GRU), Augusta, GA, USA; Department of Cellular Biology and Anatomy, Medical College of Georgia, GRU, Augusta, GA, USA

Abstract

Pathological retinal neovascularization (RNV) is a common microvascular complication in several retinal diseases including retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration and central vein occlusion. The current therapeutic modalities of RNV are invasive and although they may slow or halt the progression of the disease, they are unlikely to restore normal acuity. Therefore, there is an urgent need to develop treatment modalities that are less invasive and thus associated with fewer procedural complications and systemic side effects. This review article summarizes our understanding of the pathophysiology and current treatment of RNV in ischemic retinopathies, lists potential therapeutic targets and provides a framework for the development of future treatment modalities.

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Financial & competing interests disclosure

M Al-Shabrawey has received funding from the National Institutes of Health (1R01EY023315-01), Qatar National Research Fund (NPRP 4-1046-3-284), Georgia Regents University’s Bridge Fund and Culver Vision Discovery Institute. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

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Targeting neovascularization in ischemic retinopathy: recent advances

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Targeting neovascularization in ischemic retinopathy: recent advances

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