Lymphatic mapping and sentinel lymphadenectomy in primary cutaneous melanoma

Abstract

The management of clinically normal regional lymph nodes in early-stage melanoma has been controversial for over a century. Lymphatic mapping and sentinel lymphadenectomy (LM/SL) has been developed as a minimally invasive surgical technique to stage the regional lymph nodes without the associated morbidity of elective complete lymph node dissection. Multiple retrospective studies have validated the accuracy of LM/SL and the importance of the sentinel nodes as a staging tool for melanoma. Two multicenter, prospective, randomized trials have been performed to validate the data from the Phase II studies and determine if a therapeutic benefit exists for LM/SL.

Keywords::

• melanoma
• sentinel lymph nodes
• surgery

Financial & competing interests disclosure

This work was supported by the Ben and Joyce Eisenberg Foundation and NIH grant CA120228. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.