Hypertension to heart failure: a pathophysiological spectrum relating blood pressure, drug treatments and stroke

Abstract

Hypertension is a leading cause of major adverse cardiovascular outcomes, including heart attacks and stroke. The most visible manifestation of target organ damage related to hypertension is left ventricular hypertrophy (LVH). LVH eventually predisposes to systolic and diastolic heart failure, and is associated with an even greater risk of stroke. Electrocardiography and echocardiography are usually used to quantify LVH, but cardiac MRI may be a more reproducible and accurate modality. Regression in LVH is associated with improved cardiovascular outcomes. Treatments aimed at LVH regression include restriction of salt, regular exercise and weight reduction. Blockade of the renin–angiotensin–aldosterone system is particularly effective in preventing cardiovascular and cerebrovascular events, and is often associated with the regression of LVH, a decrease in left atrial size and a reduced incidence of new-onset atrial fibrillation, which could all contribute towards a decrease in vascular events. Overall, a reduction in blood pressure is still the most important factor in prevention of disease progression, and early treatment averts the risk of subsequent heart failure and stroke.

Keywords::

• cerebrovascular disease
• heart failure
• hypertension
• hypertension treatment

Financial & competing interests disclosure

Gregory Lip has received funding for research, educational symposia, consultancy and lecturing from different manufacturers of drugs used for the treatment of heart failure, atrial fibrillation, hypertension and thrombosis. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.