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Acknowledgements
The authors apologize to the many authors who made significant contributions to the field but whose work could not be cited due to space constraints.
Financial & competing interests disclosure
Gregor Andelfinger is a Clinician Scientist of the Canadian Institutes of Health Research. Work in his laboratory is supported by the Canadian Institutes of Health Research, Genome Québec, the Nussia and André Aisenstadt Foundation, the Heart and Stroke Foundation of Canada and the Canadian Foundation for Innovation. Paul Khairy is supported by a Canada Research Chair in Adult Congenital Heart Disease and Electrophysiology, the Canadian Institutes of Health Research and the Canada Foundation for Innovation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.