Update on the theory and management of orthostatic intolerance and related syndromes in adolescents and children

Abstract

Orthostasis means standing upright. One speaks of orthostatic intolerance (OI) when signs, such as hypotension, and symptoms, such as lightheadedness, occur when upright and are relieved by recumbence. The experience of transient mild OI is part of daily life. ‘Initial orthostatic hypotension’ on rapid standing is a normal form of OI. However, other people experience OI that seriously interferes with quality of life. These include episodic acute OI, in the form of postural vasovagal syncope, and chronic OI, in the form of postural tachycardia syndrome. Less common is neurogenic orthostatic hypotension, which is an aspect of autonomic failure. Normal orthostatic physiology and potential mechanisms for OI are discussed, including forms of sympathetic hypofunction, forms of sympathetic hyperfunction and OI that results from regional blood volume redistribution. General and specific treatment options are proposed.

Keywords::

• autonomic
• hyperpnea
• orthostatic hypotension
• orthostatic tachycardia
• postural tachycardia
• syncope

Financial & competing interests disclosure

This work was supported by the National Heart, Lung and Blood Institute (grants RO1-HL074873 and RO1-HL087803). The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.