Development of paper-based analytical kit for point-of-care testing

Abstract

Paper-based analytical devices have been widely used for biomedical, environmental and food-quality testing. This review focuses on paper-based tests for biomarkers and bacterial detection with a brief introduction about various fabrication techniques and designs, biological and nonbiological probes and detection methods. Paper is relatively cheap and available in abundance. Moreover, properties of paper such as it being disposable, easy to use and store, and that it is easy to transport and modify draw significant attention to it as a platform for the development of paper-based analytical devices. These traits make paper-based analytical devices a strong candidate in point-of-care devices for rapid and economical testing near the site of patients.

Keywords::

• biomarker
• biosensors
• lateral flow strips
• microfluidic
• micro total analysis
• paper-based immunoassay
• point-of-care testing

Financial & competing interests disclosure

The authors thank DOD TATRC W81XWH-10-1-0732 and NIH R15 ES021079-01 for financial support. This work has also been partially supported by Everglades Foundations and Kauffman Foundations. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.