Imaging cognitive and behavioral symptoms in Parkinson’s disease

Francesca Antonelli Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Canada Toronto Western Hospital and Institute, CAMH-PET Imaging Centre, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada; Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Canada Toronto Western Hospital and Institute, CAMH-PET Imaging Centre, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada

Nicola Ray Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Canada Toronto Western Hospital and Institute, CAMH-PET Imaging Centre, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada; Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Canada Toronto Western Hospital and Institute, CAMH-PET Imaging Centre, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada

Antonio P Strafella Toronto Western Research Institute and Hospital, UHN, University of Toronto, Toronto, Canada Toronto Western Hospital and Institute, CAMH-PET Imaging Centre, University of Toronto, 399 Bathurst Street, Toronto, ON M5T 2S8, Canada; PET Imaging Centre, Centre for Addiction and Mental Health, University of Toronto, Toronto, Canada;[email protected]

Abstract

Non-motor symptoms are a major and often unrecognized cause of morbidity of Parkinson’s disease. In the past few years, imaging technology, such as functional MRI and PET, have provided a large bulk of information about the phenomena. Here, we provide an overview of those imaging studies that may help us understand the neuronal correlates associated with non-motor symptoms in Parkinson’s disease, with a particular focus on cognitive and neuropsychiatric deficits.

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Acknowledgement

Antonio P Strafella is supported by Canadian Institutes of Health Research (MOP-64423) and Edmond J Safra Philanthropic Foundation.

Financial & competing interests disclosure

The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

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Imaging cognitive and behavioral symptoms in Parkinson’s disease

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Imaging cognitive and behavioral symptoms in Parkinson’s disease

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