Abstract
The understanding of the pathophysiology of primary headache disorders, especially migraine, has substantially improved over the last two decades. As a result, migraine is now mainly considered to be a disorder of the brain, rather than the vasculature or the meninges. In addition, the insights of the complex pathophysiological mechanisms and the brain structures involved in the disease facilitate the development of new therapeutic approaches. At the recent Annual Meeting of the American Headache Society in Washington (DC, USA) the latest scientific advances, as well as their clinical implications, were highlighted.
Acknowledgement
Jan Hoffmann is supported by the German Research Foundation (Deutsche Forschungsgemeinschaft, project HO4369/1-1).
Financial & competing interests disclosure
The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.