7,603
Views
55
CrossRef citations to date
0
Altmetric
Review

Memory problems in dementia: adaptation and coping strategies and psychosocial treatments

, , &
Pages 1769-1782 | Published online: 09 Jan 2014

Abstract

Memory problems are generally quite prominent in dementia and they have a significant impact on everyday functioning. Medication developed for Alzheimer’s disease, for example, acetylcholinesterase inhibitors, can slow down the increase of cognitive impairment for a while. In addition to pharmacotherapy, psychosocial treatment methods are also used, some of which have a positive effect on cognition, for example, cognitive rehabilitation, cognitive stimulation therapy and movement therapy. However, more research is needed. This article first describes the consequences of memory problems on the everyday life of people with dementia and summarizes research findings on how people with dementia experience and cope with their illness. We then discuss the most frequently applied psychosocial treatments for cognitive problems in dementia.

Medscape: Continuing Medical Education Online

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Expert Reviews Ltd. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.

Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity.

All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at http://www.medscape.org/journal/expertneurothera; (4) view/print certificate.

Release date: November 17, 2011; Expiration date: November 17, 2012

Learning objectives

Upon completion of this activity, participants should be able to:

  • •Describe memory problems in people with dementia, their impact on everyday life, and commonly used coping strategies, based on the review

  • •Describe psychosocial treatments aimed at improving the memory performance of people with dementia, based on the review

  • •Describe pharmacotherapy aimed at improving the memory performance of people with dementia, based on the review

Financial & competing interests disclosure

EDITOR

Elisa Manzotti,Editorial Director, Future Science Group, London, UK

Disclosure:Elisa Manzotti has disclosed no relevant financial relationships.

CME AUTHOR

Laurie Barclay, MD,Freelance writer and reviewer, Medscape, LLC

Disclosure:Laurie Barclay, MD, has disclosed no relevant financial relationships.

AUTHORS

Rose-Marie Dröes,VU University Medical Center, Amsterdam, The Netherlands

Disclosure:Rose-Marie Dröes has received a grant from the Foundation Vita Valley.

Henriëtte G van der Roest,VU University Medical Center, Amsterdam, The Netherlands

Disclosure:Henriëtte G van der Roest has disclosed no relevant financial relationships.

Lisa van Mierlo,VU University Medical Center, Amsterdam, The Netherlands

Disclosure:Lisa van Mierlo has disclosed no relevant financial relationships.

Franka JM Meiland,VU University Medical Center, Amsterdam, The Netherlands

Disclosure:Franka JM Meiland has disclosed no relevant financial relationships.

Dementia is a clinical syndrome. The diagnosis of dementia is made when a number of symptoms occur simultaneously Citation[1]. In most cases, memory problems are prominent and the individual also has problems with abstract thinking or judgement, language impairments, apraxia and/or trouble recognizing objects. These disorders occur when the individual is fully alert, are such that they hamper everyday functioning, and they are not a consequence of psychiatric disorders. The diagnosis of dementia is never made solely on the basis of memory problems.

There are many types of dementia. Some are treatable, such as dementia associated with a vitamin B12 deficiency or resulting from adverse drug interaction; other types are not treatable and are accompanied by progressive degeneration of the brain, such as Alzheimer’s disease, vascular dementia and frontotemporal dementia. While Alzheimer’s disease is caused by senile plaques and neurofibrillary degeneration in the cortex and gray matter of the brain, resulting in global cognitive deterioration with memory problems in the foreground in the early stage of the disease, in vascular dementia, cortical as well as subcortical parts of the brain are injured by multiple small strokes, often reflected in focal neurological symptoms besides progressive cognitive deterioration. Frontotemporal dementia is caused by degeneration of the frontal and temporal parts of the cortex and, unlike the other two types of dementia, is characterized mainly by changes in behavior. Alzheimer’s disease is the most common cause of dementia.

The drugs that were developed for Alzheimer’s disease in past decades, for example, the acetylcholinesterase inhibitors rivastigmine (Exelon®), donepezil (Aricept®) and galantamine (Reminyl®), and the NMDA-antagonist memantine (Ebixa®), at best slow down the deterioration process for a while. These drugs improve the signal transfer in the brain, which is disturbed in Alzheimer’s disease, in various ways. The first three are proven effective especially in Alzheimer’s patients with mild-to-moderately severe dementia (Mini Mental State Exam [MMSE] score between 10 and 20), and they slow down to some extent the deterioration of the thinking and memory functions, such as language and arithmetic problems, orientation and alertness, as measured with the Alzheimer’s Disease Assessment Scale Cognitive (ADAS-Cog) Citation[2,3]. This helps to maintain autonomy for a longer period of time. The (small-to-medium) effects have been confirmed on the basis of clinical observation. The last drug, memantine, is effective in moderate-to-severe dementia (MMSE <15) and to a limited degree slows down the decline of thinking, memory and executive functions as measured with cognitive tests (Severe Impairment Battery) and confirmed by clinical observation Citation[4]. In less severe dementia, only small, not clinically confirmed improvements on tests were observed (on ADAS-Cog). The Clinical Guideline for Dementia of the NICE Citation[5] advises against the use of acetylcholinesterase inhibitors and memantine in vascular dementia – except in controlled clinical trials – because the effect of these drugs is as yet insufficiently studied in vascular dementia.

The abovementioned drugs have side effects in some patients, for example, nausea, diarrhoea and fatigue. Donepezil has fewer side effects than rivastigmine. However, administering the active ingredient in the latter transdermally through a patch instead of tablets produces fewer side effects. Memantine has few side effects. Galantamine (Reminyl) is not advised for mild cognitive impairment, because of an increased risk of death.

In addition to pharmacotherapy, psychosocial treatment methods are also applied in dementia, and some of these methods have a positive effect on cognition and the behavior and mood symptoms that are common in people with dementia. They can also help people cope with their dementia.

This article consists of two sections. First, we address the way in which memory problems affect the everyday life of people with dementia, what is known from research about how people with dementia experience their illness and how they cope with it. Second, we discuss the current state of affairs with regard to psychosocial treatments aimed at improving the memory performance of people with dementia and/or supporting them in dealing with the memory and other cognitive problems in their daily lives, with the ultimate goal of improving their quality of life.

Dealing with memory problems in dementia

Memory problems are often the first manifestation of most forms of dementia. They can affect daily life in many ways. For example, people can have trouble doing the shopping, handling money, using public transport and cooking, among other things. Memory problems can also be extremely inconvenient socially if they make people forget appointments or not remember recent conversations. This can negatively impact self-confidence and well-being. Apart from memory problems we also see gradually increasing disorders of orientation in dementia (regarding places, time and persons), which leads to the individual not being able to find his/her way outside his/her home and having more and more difficulty recognizing family, friends and acquaintances; other disorders occur in understanding language and language expression (aphasia); handling objects (apraxia); and carrying out activities of daily living (e.g., washing, getting dressed and housekeeping).

How do people with dementia experience their cognitive impairments?

People with dementia differ in the degree in which they understand and are aware of their cognitive decline. Some are fully aware of it; others are considerably less aware or even completely unaware of their impairments Citation[6,7]. Research shows that there is also a large variation in how people experience their dementia. Whereas some say that they accept the disease as more or less being part of the ageing process, others indicate finding it (very) difficult to deal with the cognitive decline and the limitations this puts on their daily functioning Citation[8–10]. In summary, the problems that are experienced refer to: having to accept the worsening cognitive impairments and increasing dependency on other people; maintaining an emotional balance; maintaining contact with family, friends and acquaintances, and preventing social isolation; developing an adequate care relationship with healthcare professionals; and finally, dealing with an uncertain future and an institutional living environment Citation[11,12]. People can become insecure, their perceptions can change, they can experience anger, fear and frustration, but also changes in their social relationships and roles. As such, people with dementia are facing a set of adaptive tasks comparable to those experienced in chronic illness in general (see Box 1Citation[12]).

Adaptation & coping

People with dementia use a range of coping strategies to maintain a sense of control and balance, for example, denial, downplaying the situation, overcompensation, avoiding social contacts, withdrawing, keeping up appearances, confabulation and the use of humor Citation[7–9,11,13]. This requires energy and is emotionally draining. Intervention studies that investigated the effect of support for the different adaptive tasks on the behavior and mood of people with dementia Citation[14–17] demonstrate that offering the appropriate support can have a positive effect on the disorders in psychological functioning and on behavior Citation[12].

Memory problems: what can you do about them?

In past decades much research has been conducted into psychosocial treatment methods for dementia-related memory and cognitive disorders. For this article we studied reviews from 1990 to 2010 included in the PubMed, PsychInfo and Cinahl databases, covering publications from 1970 until April 2011. We focused our study on five most frequently used methods aimed at, and reporting on, effects on memory performance or other related cognitive skills, for instance cognitive rehabilitation, cognitive stimulation therapy (CST), memory groups, movement programs including psychomotor therapy and reminiscence (a detailed list of search terms used in this study can be obtained from the authors). We found 20 relevant reviews Citation[11,18–36]. We studied the abstracts of all relevant reviewed articles and then referenced other reviews. We furthermore searched the Cochrane Database for systematic reviews.

Psychosocial methods

In recent decades various psychosocial methods to assist and support people with dementia in coping with their cognitive problems have been applied with (some) positive results Citation[12,36,37]. These methods focus on: stimulating the individual’s functioning and preventing ‘excess disabilities’ through global or specific cognitive stimulation and exercise (e.g., reality orientation training, cognitive rehabilitation, CST, memory groups, movement therapy and bright light therapy) or by the application of compensatory aids (e.g., assistive technology); and on the psychological acceptance of, and dealing with, cognitive limitations to improve the quality of life, for example, reminiscence, activity groups, psychomotor therapy, validation and behavior therapy. The methods frequently target a combination of different objectives Citation[12].

Between 1970 and 1990 emphasis was on practicing skills and the (re)activation of cognitive functions; for example, by cognitive stimulation and reality orientation training. A basic principle was that people with a mild form of dementia still have the ability to store information and stimulating their cognitive reserve can therefore benefit them Citation[38]. In the 1990s, owing to the limited results of using only cognitive stimulation and the negative consequences that resulted from the repeated confrontation with one’s limitations, the focus shifted to so-called emotion-oriented, psychosocial approaches, such as psychomotor therapy, activity groups, validation therapy and reminiscence. The latter approaches aim to support and assist the person with dementia, not only in coping with the cognitive consequences of the disease, but also and especially with the emotional and social consequences. An important goal of these methods is also to maintain communication and contact with persons with dementia and to prevent them from becoming socially isolated and lonely. The activities are attuned to individual abilities and limitations and are compatible with the individual’s experiences. Psychomotor therapy, activity groups and reminiscence therapy are especially suitable for people with mild-to-moderate dementia, while validation can be applied in more advanced stages of the disease, when the individual lives in his own world of experience. Each of these approaches appears to be of value for the cognitive, emotional and/or social adaptation, as research shows Citation[11,16,19,37], although further research is recommended as the quality of the studies is often mediocre.

In the past 10 years, there has been an upsurge in the study of cognitive stimulation in Europe (including in the UK, France, Italy and Spain) and in the USA Citation[39,40], partly because of improved early diagnostics. However, the methods now aim to accommodate the variation in individual needs, desires and cognitive capacities of people with dementia. The results are hopeful. Especially in early-to-moderate dementia, cognitive stimulation along these lines can result in (some) improvement in cognitive functioning if it focuses on the individual problems and needs of the person with dementia and their cognitive capacities Citation[40].

We will present an overview of the proven effects on memory and other cognitive functions of the most frequently used psychosocial methods, namely: cognitive rehabilitation, CST, memory groups, movement programs and psychomotor therapy, and reminiscence.

Cognitive rehabilitation & cognitive training

Cognitive rehabilitation is defined as: “any intervention strategy or technique which intends to enable clients or patients, and their families, to live with, manage, by-pass, reduce or come to terms with deficits precipitated by injury to the brain” Citation[41]. After identifying goals that are relevant to the individual in question, strategies are designed and followed to achieve these goals Citation[42]. In the case of a progressive disease, such as Alzheimer’s disease, the goals obviously need to be adjusted as time passes Citation[43]. In the early stages of dementia, emphasis is on coping with cognitive changes, such as memory and orientation problems, and their impact on everyday life and relationships (e.g., participation in activities and social participation). At that stage people often still have the capacity to learn new information, retain that which is learned, improve their practical skills and adapt their behavior. This is possible because the implicit or procedural memory is still intact Citation[21,44]. Although it is more difficult to absorb new information in early dementia, memories can be retained once they are stored. And that means that improvement of memory and daily functioning are basically possible with the correct assistance.

Clare describes two ways in which cognitive rehabilitation can address memory problems in the early stages of dementia Citation[43]:

  • • First, by building on the memory skills a person still has: this refers to continuing to practice activities of daily living and other skills by means of offering structured exercises/activities; the person receives instructions, offered through images, gestures or in writing (these instructions can be dropped gradually when the activity becomes routine: ‘vanishing cue’ technique). Different techniques are used in the training process, for example, ‘spaced retrieval’ and ‘errorless learning’;

  • • Second, by using compensatory aids when memory fails, for example, the use of a calendar or diary, a memory or life book with important personal information, stickers or signs on doors and cupboards indicating their function or content. Finally, lists can be made of how to carry out a practical task (making coffee or operating the washing machine). Obviously these types of aids are only useful if the individual understands what they are for and he/she uses them regularly, so it becomes a habit. The people around the individual can stimulate their use by reminding him/her. When using the aid gradually becomes routine, the need for this encouragement will decline.

Cognitive rehabilitation can be offered individually Citation[45], as well as in families Citation[46], in a group Citation[47], as part of a broader psychosocial intervention Citation[48] or by means of a computer program Citation[49,50]. Apart from professionals, informal carers, friends or volunteers can also be involved.

Clare has described extensive guidelines for cognitive rehabilitation; for example, that it Citation[43]:

  • • Must focus on individual goals that are realistic, practically relevant and meaningful for the individual;

  • • Must be based on the assessment of individual cognitive abilities, including memory skills and memory problems, and also must be based on observation of functioning in daily life;

  • • Must be based on agreement between the client and therapist on the goals of the intervention and the methods to be used.

In an (uncontrolled) study among six individuals with Alzheimer’s disease, Clare et al. found that the method described above, which is partly based on the ‘errorless learning’ principles, demonstrated an improvement in everyday memory problems Citation[51]. Very recent research that compared the effect of cognitive rehabilitation in people with mild Alzheimer’s disease and/or vascular dementia (MMSE >18; n = 23) with ‘relaxation exercises’ (n = 24) and ‘no treatment’ (n = 22) in a randomized controlled trial (RCT), showed that the individuals who had received cognitive rehabilitation (eight sessions, in accordance with method above) performed better on the personal goal activities they formulated beforehand (such as remembering chores to do in and around the house, learning to use a mobile phone and maintaining concentration while cooking) and were more satisfied Citation[42]. When an informal carer was involved in the intervention the individual performed better than those who participated without an informal carer, thanks to more frequent practise between therapy sessions when an informal carer was involved. For the informal carers their quality of life improved. The behavior changes in the person with dementia were supported by MRI data (increased activity in certain brain areas) that were available on part of the individuals. After the 6-month follow-up the cognitive rehabilitation group performed better on a memory test. This improvement on the trained functional tasks and memory after cognitive rehabilitation and at follow-up (after 3 months) was also found by Loewenstein et al. who investigated a 24-session rehabilitation program Citation[52]. They also reported not finding a generalizing effect on other neuropsychological measures as a result of the training.

Earlier studies also demonstrated the effect of cognitive training on memory (on recall in particular) and the attention of people with (Alzheimer’s) dementia Citation[23,53–55]. Controlled studies of the effect of reality orientation training (ROT) in the 1980s already showed effects on cognition, more specifically on memory and orientation, after 8–12 weeks of training Citation[20,56]. Later research showed that longer programs (8–40 weeks) are more effective than a short program (4 weeks) to combat cognitive decline and postpone nursing home admission Citation[57]. The recently studied combination treatment of ROT and anti-Alzheimer medication (donepezil) – investigated earlier by Cahn-Weiner et al. who found a medium improvement of recall and recognition after 6 weeks of training Citation[58] – proved more effective than medication alone Citation[59]. After only 3 weeks of daily ROT and movement activation, in which informal carers also participated, the combination therapy already yielded a significant improvement on the MMSE, whereas medication alone did not show any significant improvement. After 2 months, during which the informal carers continued the therapy at home, the MMSE improvement was still present. The effectiveness of techniques, such as ‘errorless learning’, ‘spaced retrieval’, ‘vanishing cues’ and external memory aids (e.g., a diary) was also confirmed in research Citation[60].

Yu et al. conclude on the basis of a comprehensive review of the literature that cognitive training in the early stages of Alzheimer’s disease improves cognition, activities of daily living and decision-making Citation[40]. The interventions are more effective when carried out in a structured manner, are aimed at specific functions affected by dementia and are at the individual residual capacity, or combined with cognition-enhancing medication. The effects are generally medium (d = 0.47; Citation[61]).

Recently several studies also investigated the effect of computer-assisted cognitive training programs. A small (n = 6) uncontrolled American study demonstrated that an intensive 6-week cognitive training program among elderly with moderate-to-severe dementia can lead to a general improvement of the cognitive functions, including short-term memory Citation[62]. In an RCT with 46 people with a mild form of Alzheimer’s dementia, a Spanish study measured the effect of the Multimedia Cognitive Stimulation program ‘Smartbrain’ (frequency: 3 × 20 min/week over a period of 24 weeks) in combination with a daily psychostimulation program (8 h a day in day treatment) and the use of cholinesterase inhibitors (group 1), compared with day treatment in combination with cholinesterase inhibitors (group 2) and the use of cholinesterase inhibitors alone (group 3) Citation[49]. After 12 weeks positive effects (improvements) were found for both combination treatment groups (1 and 2) on cognition (ADAS-Cog and MMSE) in comparison with the medication group (group 3). For group 1 these effects persisted up to the follow-up after 24 weeks. After 24 weeks group 2 scored better than group 3 only on the MMSE. This proves that cognitive stimulation in combination with traditional activation in day treatment and anti-Alzheimer’s disease medication is more effective that medication alone, and enhances the effects of traditional activating day treatment.

Cognitive stimulation therapy in a group setting

CST is a brief group therapy for people with mild-to-moderate dementia, based on the theoretical concepts of reality orientation training and cognitive stimulation. CST combines the elements of both methods that are proven to be effective Citation[39,63]. CST is different from cognitive rehabilitation in that it is a more global approach that focuses on cognitive functioning (attention/concentration, orientation, different types of memory, visual constructive abilities, executive functions and verbal fluency), as well as on psychosocial functioning (self-confidence, motivation, socialization and affective condition) Citation[38]. Furthermore, it is generally carried out in a group (or together with the informal carer) and the activities do not consist primarily of practicing situations/activities that require specific cognitive skills, as is the case in cognitive rehabilitation, or training cognitive functions as in cognitive training Citation[39,63].

The therapy as developed in the UK by Spector Citation[63] consists of 14 sessions lasting 45 min over a period of 7 weeks, in which activities are carried out based on particular themes, for example: childhood, current affairs, nutrition, numbers and word games, quiz, word association/conversation, sound, being creative, physical games, orientation, categorizing objects, using money and familiar faces. The activities are offered in a stimulating, pleasant and flexible way that is compatible with the needs and abilities of the group, by a person who is trained in the CST method. They follow an established pattern (introduction/goodbye, warming up and cooling down activities and a familiar activity, such as a song; the main activity is different each week) Citation[64]. Different media and sensory stimuli are used to enhance communication and stimulate thought processes. For example, for the childhood theme, candy, songs and games are used.

This CST program was studied in an RCT for its effect on cognition, and it turned out to have positive effects on cognition that were comparable to cholinesterase inhibitors in people with Alzheimer’s disease. The improved cognition also increased the quality of life of the people who received CST Citation[65]. Finally, economic analysis revealed that CST was also cost effective Citation[66]. For this reason the NICE guidelines have recommended this therapy in the UK since 2006 for people with mild-to-moderate dementia Citation[5].

A maintenance version of the English CST program (Maintenance CST; MCST) was recently studied in a controlled pilot, in which CST, after first being offered twice a week for a period of 7 weeks, was continued for another 16 weeks at a frequency of one session per week Citation[67]. MCST was proven to result in a significant improvement on the MMSE. In the context of the Support at Home: Interventions to Enhance Life in Dementia research program (SHEILD) a large-scale RCT is presently being conducted in the UK among 230 people with dementia (Alzheimer’s disease and other types of dementia) into the effect of this maintenance therapy that – after 7 weeks of CST (two sessions/week) – offers MCST (one session/week) over a period of 24 weeks Citation[68].

French research into a comparable 7-week cognitive stimulation program showed that after the program the participants performed better on a memory test where they had to reproduce a shopping list and remember where objects were located inside a house Citation[69]. An RCT conducted by Breuil et al. into CST also found effects on memory (episodic memory and remembering a list of words), as well as on orientation in space and time Citation[70]. Finally, research by Vidal et al. found significant improvement on the MMSE (two points) after CST and a trend of fewer problems in everyday functioning Citation[71].

Italian research revealed that global cognitive stimulation through recreational activities had more effect on behavior problems and skills in daily activities, than specific cognitive training of the procedural memory for activities of daily living and cognitive rehabilitation of residual functions Citation[72]. Furthermore, at the 6-month follow-up the informal carers of the global stimulation group experienced less stress.

Memory groups for people with early dementia

Memory groups aim to help people with early dementia (MMSE score >22 of 30) with their memory problems by teaching them different strategies and techniques (generally based on the principles of cognitive rehabilitation), so that they can continue to lead the life they are accustomed to Citation[73]. For example, by using aids, such as calendars, a timer, a dictaphone and basic techniques to remember and retrieve memories in different situations. The expectation is that once the individual has learned these techniques, he/she will also apply them in other situations. Memory groups are suitable for people who realize that they have memory problems, are motivated to do something about it and are able to communicate in a group setting. It proves to be advantageous if the informal carer supports the individual’s participation Citation[73].

The use of memory groups is widespread, for example, in memory clinics, rehabilitation centers, regional mental health services and Alzheimer’s disease foundations. Burnham describes the general procedure in a memory group: the participants are asked to work out which skills they most want to retain and are subsequently encouraged to train these skills Citation[73]. The core techniques taught in the different situations are: repetition, retrieving memories regularly, association with something or someone the individual already knows, use of rhyme, alliteration, use of aids and utilizing habits. In addition, the participants are encouraged to find out what kind of information (e.g., text, pictures or sound) work best to help them remember and retrieve things from their memory. The teaching material is drafted in simple language with many explanatory illustrations and the participants are encouraged to discuss it with a relative or friend. The memory group meets 6- to 12-times, depending on the participants’ needs, and is preferably led by two persons (e.g., psychologist, occupational therapist or social psychiatric nurse). Before participation and after the group each participant is visited at home to see how the learned techniques can be applied in the home situation and what the family or the informal care can do to assist.

Case studies show that these memory groups have a positive effect on cognitive (process) skills and the effective use of aids in daily life, resulting in more independent functioning Citation[73]. Various scientific studies also demonstrate that memory groups can be successful in early dementia: the individual learns to use aids and strategies, cognitive functioning, as measured with the MMSE, stabilizes to some degree and mood can improve Citation[74,75]. Research by Lipinska et al. has shown that self-generated instructions/associations (‘cues’) are more effective for remembering and retrieving memories than instructions designed by others (healthcare professionals/informal carers) Citation[76]. This is an argument in favor of the method described above, which is tailored to the individual.

Movement programs & psychomotor therapy

Movement programs for people with dementia are applied from different therapeutic perspectives: cognitive and neurophysiological, holistic, behavior therapeutic and psychodynamic/interactional Citation[77]. The programs based on a cognitive and neurophysiological perspective generally utilize movement activities from physical training, fitness training, sports and games. Regular physical exercise aims to stimulate the individual as an information-processing system and to positively influence the neurophysiological or pathophysiological processes underlying the (disturbed) system Citation[78]. The ‘use it or lose it’ theory fits well in this perspective.

The programs from a holistic perspective are aimed at the recovery of the bio–psycho–socio system and, in addition to movement exercises to stimulate self-expression, self-image and self-esteem, also utilize music, breathing exercises, informal conversation and nutritional education as therapeutic tools Citation[77].

The behavior therapeutic programs are based on principles from learning theory (learning through the positive consequences of particular behaviors). They utilize verbal rewards and games with an intrinsic reward (e.g., ninepins and goal kicking) in order to (re)activate and adjust behavioral problems Citation[77].

Psychodynamically (interactional) oriented movement therapy programs start from the assumption that behavior and mood disorders in dementia are partly caused by psychological reactions of people with dementia to their cognitive disorders and the changed relationship with the environment. They offer movement activities in which the participants can experience some degree of success and confidence in themselves and others again Citation[77]. In this way they learn to cope with their own disabilities, an appeal is made on them to (re)engage with their environment and the emotional balance is restored. Depending on the stage of the dementia, extra attention is given to coping with cognitive impairments and emotional support (mild dementia), social contact and safety (moderate dementia), and sensory experiences and contact (severe dementia).

A 2004 systematic review and meta-analysis of randomized clinical trials of the effect of movement on people with dementia and related cognitive disorders (n = 2020) shows that regular physical exercise, such as walking, chair exercises, dancing, weight training and riding on a bicycle ergometer, apart from affecting the level of fitness (cardiovascular and BMI), physical functions (strength and flexibility), daily functioning and positive behavior, also has a positive effect on cognitive functions, such as attention, executive functions and language Citation[25,79]. The effects on health-related physical fitness are medium to large (d > 0.5 to d > 0.8; Citation[80]), and are generally medium (d = 0.5) for cognitive, functional and behavior outcomes. Later studies also show the effect of movement on cognition. A study (RCT) carried out in Belgium showed a significant improvement on cognition (three points or more on MMSE) in people with dementia who participated in moving to music for 30 min every day for a period of 3 months, whereas no change was observed in the control group Citation[81]. A very recent RCT conducted in the UK Citation[82] shows that after only 6 weeks of participation in (anaerobic) movement activities elderly people with Alzheimer’s disease improved on attention, visual memory and working memory as compared with a control group that had deteriorated on these aspects.

Several (nonrandomized) controlled studies (including Citation[83,84]) also showed that simple (anaerobic) movement activities have a (brief) positive influence on the general cognitive functioning of elderly people with dementia, more specifically on: immediate memory, recognition, word fluency and logical memory.

Movement activation, such as psychodynamically-oriented psychomotor group therapy was examined in an RCT among elderly people with mild-to-moderately severe dementia of the Alzheimer type (n = 40) in nursing homes Citation[11,18,77]. The experimental group received psychomotor therapy (for 7 months, three-times a week for 45 min), while a control group was offered activity therapy in the same period and with the same frequency. In comparison with activity therapy, psychomotor group therapy had a more positive effect on the satisfaction of the participants, aggression and night-time restlessness. The latter two (aggression and night-time restlessness) stabilized in the therapy group, whereas they increased in the control group (also see Citation[85,86]). During the therapy sessions, however, statistically significant improvements were also found on memory, liveliness and initiative. The same movement activation program as the one investigated by Dröes was studied in an RCT among people with cognitive disorders on psychogeriatric wards in homes for the elderly by Hopman-Rock et al.Citation[87]. They found positive effects on cognition and social behavior.

Reminiscence

In reminiscence activities, events and experiences from the past are discussed in one-on-one or group conversations Citation[88]. Aids are often used, such as videos, photographs, newspaper clipping books, scrapbooks and life story books. The objective of reminiscence is to offer a pleasant activity and a tool to maintain communication with others Citation[89,90]. In addition, reminiscing together can also provide recognition and emotional support (also to the informal carer) in coping with the changes or losses that individuals go through as a result of the dementia. The method is useful especially for elderly people in the early stages of dementia, when, despite the short-term memory problems, they can still access memories from the past relatively easily.

Although reminiscence is a very popular method and is used widely for people with dementia Citation[91], its effectiveness in dementia has not been studied extensively, and generally only in small, uncontrolled studies. Woods et al. indicate in their systematic review that only four small randomized controlled trials, of relatively poor quality, on the effect of reminiscence (group) therapy have been conducted on people with dementia Citation[88]. Four to six weeks after the treatment they show a significant improvement in cognition and mood and a reduction of stress in the informal carers who participated in the groups. The informal carers also indicated that the persons with dementia functioned better at home. The results of more recent RCTs do not provide unambiguous results. One Taiwanese study (RCT) of reminiscence groups (1 h/week for 8 weeks) among 102 individuals with dementia showed significant improvements on the MMSE and the Cornell Scale for Depression Citation[92]. However, a smaller RCT study of reminiscence groups (1 h/week for 3 months) among people with vascular dementia (n = 60) in Japan found no significant effect on cognitive functioning or mood Citation[93].

Other (un)controlled studies of reminiscence in a group setting show positive effects on the cognitive, social and emotional domain Citation[18,19]; for example: general cognitive functioning, improvement of interest, interaction and social behavior and fewer behavior problems (including agitation, aggression and unrest). Positive effects were also described on feelings of self-esteem, acceptance of past and present, and expectations for the future of people with dementia.

Studies of individual reminiscence among elderly people with dementia show positive effects on social behavior, aggression Citation[89], sense of identity and enjoyment Citation[94]. Persons with severe cognitive impairments have shown increased involvement in their environment Citation[90].

In the UK, a large multicenter RCT (RemCare) is being conducted into the effect and cost–effectiveness of reminiscence groups for people with dementia and their informal carers (3 months of weekly meetings, 7 months of monthly meetings)Citation[95]. Two hundred dyads that participate in the reminiscence groups are compared with 200 dyads that receive usual care. The primary outcome measure is quality of life, the secondary outcome measures are: autobiographical memories; quality of relationship between people with dementia and informal carers; and the degree of depression and experienced anxiety of people with dementia and their informal carers.

Conclusion

This article has addressed how people with dementia experience and cope with their cognitive disorders, and discussed several psychosocial treatment methods that are applied to help people with dementia cope with their cognitive limitations in daily life, maintain an emotional balance and maintain social contact with other people in their environment. So far, evidence for the effect of the described methods on memory and other cognitive functions is limited, because often the applied research methods were weak and the actual implementation (and characteristics) of the interventions differed, which makes it difficult to draw firm conclusions regarding the effectiveness of these interventions. However, the described interventions are promising, with the best evidence found for individually tailored cognitive rehabilitation, CST in a group setting and movement programs. The effects are medium and comparable to (and sometimes even larger than) the effects on cognition of anti-Alzheimer’s disease medication. An added advantage is that they do not have the side effects that these drugs may have. Several recent studies indicate that a combined treatment of cognitive stimulation and acetylcholinesterase inhibitors results in better effects than medication alone. Further research is recommended.

Other methods that may also have a positive effect on cognitive functioning, or may slow down cognitive decline, such as activating day treatment programs, activity groups, validation therapy, normalization of the living environment, small-scale living facilities, light therapy and supportive technology, were not discussed here. The relevant research, if conducted, generally shows that as yet, there is insufficient evidence to draw conclusions about the effectiveness of these methods on cognition Citation[31,36,96,97]. Again, more scientific research is advisable.

Expert commentary

Since the 1960s psychosocial treatment methods have been used to support people with dementia and their relatives in coping with the consequences of dementia, including cognitive problems. Also, for many years research has been looking into the effects of different psychosocial treatment methods on cognition, behavior and mood problems, quality of life and delayed nursing home admission of people with dementia and on experienced burden, physical and mental health and quality of life of their informal carers. In this article we described the found effects on memory and other cognitive functions, such as attention, orientation, interest, sense of identity and daily functioning, of cognitive rehabilitation, CST, memory groups, movement programs and psychomotor therapy, and reminiscence.

Studies in the past have varied in quality, and points of criticism include small research populations, mediocre research designs, incomplete descriptions of interventions and a lack of a theoretical framework for the interventions Citation[35,98]. Although more thorough and larger-scale RCTs have been conducted in the past decade Citation[99], results still do not allow firm conclusions regarding the effectiveness of the described interventions. The analysis of research results presented here warrants the conclusion that most evidence for the effectiveness on cognitive functioning has been found for movement programs and to a lesser extent for cognitive rehabilitation and cognitive stimulation in a group setting. What is the significance of these findings for everyday practice? When treatment is considered for a cognitively impaired person with dementia, a psychosocial treatment is preferred over medication treatment, as the latter generally is not more effective and has more side effects than psychosocial treatment methods. Furthermore, of the many available psychosocial treatment methods, the most evidence-based and promising treatment methods are preferred; for example, the abovementioned movement programs, cognitive rehabilitation and cognitive stimulation in a group setting. It is, therefore, important that these treatment methods find their way into practice and are implemented on a large scale. This can be stimulated by including proven effective interventions in the guidelines for care and support in dementia, just like, for example, CST was included in the NICE guidelines in the UK. At the European level there are also some good initiatives. In the European network of researchers on Early and Timely Interventions in Dementia (INTERDEM), for example, forces are joined to stimulate the development, evaluation and implementation of evidence-based psychosocial treatment methods Citation[99]. Because their effectiveness has been insufficiently or not yet demonstrated, further research is advisable for some of the psychosocial treatment methods described here, before implementing them on a large scale. Furthermore, it is necessary to obtain consensus regarding the outcome measures that are used Citation[100]. Obviously, they need to have good psychometric properties, but they should also be attuned to the effects in daily life that the intervention focuses on. In this respect, the commonly used MMSE, for example, can be brought up for discussion. First, this instrument is a diagnostic screening instrument and not intended for measuring treatment effects. Second, if this instrument showed treatment effects it is not clear whether several points of change on the MMSE have a clinically relevant impact on the daily life of persons with dementia. It would be worthwhile to know whether memory improvement has a generalizing effect on other domains of daily life, such as engaging in more social contacts, improved self-esteem or autonomy, giving meaning to one’s life or better quality of life as a whole. This would be very relevant for clinical practice and ultimately for the person with dementia himself.

Related to this issue is how ‘evidence-based treatment methods’ may be successfully implemented in personalized dementia care, because positive research results do not guarantee effectiveness in clinical practice, where people will want to know whether an intervention will be effective for an individual client and what is the best way to offer the intervention (by whom, how and what frequency). The different studies do not always provide clear answers on this and so there is a challenge for researchers to investigate more extensively what specific treatment methods are effective for which (sub)groups in which circumstances Citation[37]. Today there is consensus that, regardless of the intervention chosen, the starting point must be that it is attuned to the specific wishes, preferences, abilities and needs of the person with dementia. Positive research results and inclusion of the treatment methods into guidelines are important preconditions for a wide implementation of psychosocial treatment methods in practice, but this is not sufficient. It takes more to successfully implement interventions in actual practice. It requires support in different echelons of an organization (management level and executive level), staff need to be trained and adequate financial resources are necessary to carry out the interventions. The current financial and political climate in The Netherlands and other European countries is not very favorable in this respect, and we will have to pull out all the stops to guarantee continued best possible care for people with dementia in the future.

Five-year view

Although in previous decades there has been much research to help people with dementia cope with their cognitive impairments, compared with cancer and cardiovascular disease research grants for dementia research lag behind. The budget for dementia research is less than 5% of the cancer research budget Citation[101]. This is out of proportion to the social costs of dementia care: in high-income countries these far outweigh the social costs of other chronic diseases Citation[102]. Furthermore, the number of people with dementia is expected to double approximately every 20 years, up to 115.4 million in 2050 worldwide Citation[102]. It is therefore necessary to free up more funds for dementia-related research. The large majority of dementia studies involve fundamental research, aimed at early diagnosis, functioning of memory and medication. However, many nonpharmacological treatment methods, for example, psychosocial or psychological treatment methods, have been proven to be at least as effective as pharmacological therapies Citation[35], and the absence of side effects warrants more attention for nonpharmacological treatment methods in research. This is also recommended in the recently published European Dementia Research Agenda Citation[201].

The positive effects on cognition of cognitive rehabilitation, cognitive stimulation and memory groups for people with dementia have as yet not been generally confirmed in large-scale RCTs, and the studies have frequently been conducted in homogeneous populations only. To examine whether the results of these interventions also apply to subgroups, high-quality RCTs are required in the future, preferably in an international context. In addition to the effectiveness of interventions, we also recommend cost–effectiveness studies in order to facilitate the implementation of effective interventions. At present there are three large-scale RCTs that also focus on cost–effectiveness: SHIELD (Maintenance Cognitive Stimulation Therapy Citation[68]), RemCare (reminiscence groups Citation[95]) and WHEDA (occupational therapy Citation[103]). The results of these studies are important for the future of dementia treatment methods, and the results are eagerly anticipated.

The research agenda for dementia-related research for the next 5 years has some important focal points. First of all international, national and local authorities, healthcare insurers and companies must reserve more budget to be able to increase dementia research. It is up to the dementia experts to raise awareness among authorities and policy-makers regarding the significant increase of people with dementia in the near future and the enormous additional social costs. Second, to make the (financial) added value of treatment methods visible, future research must also focus on cost–effectiveness. Third, future research should focus not only on early diagnosis, but also on psychosocial and psychological therapies, to preserve cognitive functions for a longer period of time. Memory performance is an important outcome measure, because it greatly impacts everyday life, but further research into how psychosocial therapies may benefit other cognitive domains that also affect the quality of life of people with dementia, such as attention, interest, sense of identity, praxis and language, is needed as well. In addition to attention for promising treatment methods, such as cognitive rehabilitation, movement programs and combined interventions, the effects on cognition of the interventions that have not been thoroughly investigated yet must be explored further, for example, memory groups, activating day treatment and validation therapy. It is important to use high-quality study designs, with multiple settings and international collaboration to enable subgroup research. Finally, attention should be given to new innovative methods, such as the use of assistive technology. Information communication technology has great potential because of the possibility of personalizing individual interventions, the application in home situations and intramural settings and reducing the burden on professional and informal carers. Examples of such projects are ROSETTA Citation[202] and Computerized Personal Interventions for Alzheimer’s Patients, which uses computerized systems for reminiscence therapy and cognitive training Citation[203].

The further development of early and timely treatment methods remains necessary to be able to offer efficient care to people with dementia, now and in the future.

Box 1. Adaptive tasks in dementia.

  • • Coping with one’s own disabilities

  • • Preserving an emotional balance

  • • Maintaining a positive self-image

  • • Preparing for an uncertain future

  • • Dealing with the day care, care home or nursing home environment and treatment procedures

  • • Developing an adequate care relationship with healthcare professionals and staff

  • • Developing and maintaining social relationships

Key issues

  • • There is much diversity in how people with dementia experience dementia, including memory problems.

  • • People with dementia face several adaptive tasks comparable to those experienced in chronic disease in general, such as coping with one’s own disabilities, preserving an emotional balance and coping with an uncertain future.

  • • People with dementia use a variety of coping strategies, such as denial, overcompensation, downplaying, regression, avoiding problems and social contact, and humor, to deal with the consequences of dementia in daily life.

  • • In the last three decades, several drugs have been developed that can improve, or stabilize, the cognitive and daily functioning of people with Alzheimer’s disease. Examples are the acetylcholinesterase inhibitors rivastigmine, donepezil and galantamine, and the NMDA antagonist memantine.

  • • Several nonpharmacological psychosocial treatments, such as cognitive rehabilitation, cognitive training, cognitive stimulation therapy, memory groups, movement activation and reminiscence, aim to improve the cognitive functioning of people with dementia, including memory.

  • • The evidence for the effect of psychosocial treatments on cognition is still limited. Most evidence exists for movement activation, cognitive rehabilitation attuned to individual needs, and cognitive stimulation therapy in groups.

  • • The effects of psychosocial treatments are comparable with, or better than, the effects of available anti-Alzheimer’s disease drugs.

  • • Some studies show a surplus value of combination therapy, combining psychosocial treatment with anti-Alzheimer’s disease medication.

References

  • American Psychiatric Association. DSM-IV-TR: Diagnostic and Statistical Manual of Mental Disorders. American Psychiatric Press Inc., Arlington, VA, USA (2000).
  • Birks J. Cholinesterase inhibitors for Alzheimer’s disease. Cochrane Database Syst. Rev.1, CD005593 (2006).
  • Birks J, Grimley Evans J, Lakovidou V, Tsolaki M. Rivastigmine for Alzheimer’s disease. Cochrane Database Syst. Rev.2, CD001191 (2009).
  • McShane R, Areosa Sastre A, Minakaran N. Memantine for dementia. Cochrane Database Syst. Rev.2, CD003154 (2006).
  • NICE-SCIE. Clinical Guideline Number 42. Dementia: Supporting People with Dementia and their Carers in Health and Social Care. NICE, London, UK (2006).
  • Phinney A. Fluctuating awareness and the breakdown of the illness narrative in dementia. Dementia1(3), 329–344 (2002).
  • Clare L. Managing threats to self: awareness in early stage Alzheimer’s disease. Soc. Sci. Med.57, 1017–1029 (2003).
  • Clare L. We’ll fight it as long as we can: coping with the onset of Alzheimer’s disease. Aging Ment. Health6, 139–148 (2002).
  • Steeman E, Godderis J, Grypdonck M, Bal N de, Dierckx de Castele B. Living with dementia from the perspective of older people: is it a positive story? Aging Ment. Health11(2), 119–130 (2007).
  • De Boer ME, Hertogh CMPM, Dröes RM, Riphagen II, Jonker C, Eefsting JA. Suffering from dementia: the patient’s perspective; an overview of the literature. Int. Psychogeriatr.19(6), 1021–1039 (2007).
  • Dröes RM. [In Motion; On Psychosocial Care for Demented Elderly]. Vrije Universiteit. Intro, Nijkerk, The Netherlands (1991).
  • Dröes RM, van Mierlo LD, van der Roest HG, Meiland FJM. Focus and effectiveness of psychosocial interventions for people with dementia in institutional care settings from the perspective of coping with the disease. Non Pharm. Ther. Dement.1(2), 139–161 (2010).
  • LaBarge E, Trtanj F. A support group for people in the early stages of dementia of the Alzheimer type. J. Appl. Gerontol.14, 289–301 (1995).
  • Dröes RM, Breebaart E, van Tilburg W, Mellenbergh GJ. The effect of integrated family support versus day care only on behavior and mood of patients with dementia. Int. Psychogeriat.12(1), 99–116 (2000).
  • Dröes RM, Meiland FJM, Schmitz M, van Tilburg W. Effect of combined support for people with dementia and carers versus regular day care on behaviour and mood of persons with dementia: results from a multi-centre implementation study. Int. J. Geriatr. Psychiatry19, 1–12 (2004).
  • De Lange J. Dealing with dementia. Effects of Integrated Emotion-Oriented Care on Adaptation and Coping of People with Dementia in Nursing Homes; A Qualitative Study as Part of a Randomized Clinical Trial. PhD-Thesis. Erasmus University, Rotterdam, The Netherlands (2004).
  • Finnema E, Dröes RM, Ettema TP et al. The effect of integrated emotion-oriented care versus usual care on elderly persons with dementia in the nursing home and on nursing assistants; a randomized clinical trial. Int. J. Geriatr. Psychiatry20(4), 330–343 (2005).
  • Dröes RM. Psychosocial treatment for demented patients; methods and effects. In: Care-giving in dementia II. Miesen B, Jones G (Eds). Routledge, Abingdon, UK, 127–148 (2004).
  • Finnema E, Dröes RM, Ribbe M, Tilburg W van. The effects of emotion-oriented approaches in the care for persons suffering from dementia; a review of the literature. Int. J. Geriatr. Psychiatry15(2), 141–161 (2000).
  • Spector A, Davies S, Woods B, Orrell M. Reality orientation for dementia: a systematic review of the evidence of effectiveness from randomised controlled trials. Gerontologist40, 206–212 (2000).
  • De Vreese LP, Neri M, Fioravanti M, Belloi L, Zanetti O. Memory rehabilitation in Alzheimer’s disease: a review of progress. Int. J. Geriatr. Psychiatry16(8), 794–809 (2001).
  • Cohen-Mansfield J. Nonpharmacologic interventions for inappropriate behaviors in dementia: a review, summary, and critique. Am. J. Geriatr. Psychiatry9(4), 361–381 (2001).
  • Bates J, Boote J, Beverly C. Psychosocial interventions for people with a milder dementing illness: a systematic review. J. Advanced Nursing45(6), 644–658 (2004).
  • Fritschy EP, Kessels RPC, Postma A. [External memory aids in patients with dementia: a literature study on efficacy and applicability]. Tijdschr. Gerontol. Geriatr.35, 234–239 (2004).
  • Heyn P, Abreu BC, Ottenbacher KJ. The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Arch. Phys. Med. Rehabil.85, 1694–1704 (2004).
  • Livingston G, Johnston K, Katona C, Paton J, Lyketsos CG. Systematic review of psychological approaches to the management of neuropsychiatric symptoms of dementia. Am. J. Psychiatr.162, 1996–2021 (2005).
  • Overshott R, Byrne J, Burns A. Nonpharmacological and pharmacological interventions for symptoms in Alzheimer’s disease. Expert Rev. Neurother.4(5), 809–821 (2004).
  • Teri L, McKenzie G, LaFazia D. Psychosocial treatment of depression in older adults with dementia. Clin. Psychol.12(3), 303–316 (2005).
  • Verkaik R, van Weert JC, Francke AL. The effects of psychosocial methods on depressed, aggressive and apathetic behaviors of people with dementia: a systematic review. Int. J. Geriatr. Psychiatry20(4), 301–314 (2005).
  • Eggermont L, Swaab D, Luiten P, Scherder E. Exercise, cognition and Alzheimer’s disease: more is not necessarily better. Neurosci. Biobehav. Rev.30(4), 562–575 (2006).
  • Lauriks S, Reinersmann A, van der Roest HG et al. Review of ICT-based services for identified unmet needs in people with dementia. Ageing Res. Rev.6(3), 223–246 (2007).
  • Smits CH, De Lange J, Dröes RM, Meiland F, Vernooij-Dassen M, Pot AM. Effects of combined intervention programmes for people with dementia living at home and their caregivers: a systematic review. Int. J. Geriatr. Psychiatry22(12), 1181–1193 (2007).
  • Burgener SC, Buettner L, Buckwalter KC et al. Review of exemplar programs for adults with early-stage Alzheimer’s disease. Res. Gerontol. Nurs.1(4), 295–304 (2008).
  • Nijhof N, van Gemert-Pijnen JE, Dohmen DA, Seydel ER. Dementia and technology. A study of technology interventions in the healthcare for dementia patients and their caregivers. Tijdschr. Gerontol. Geriatr.40(3), 113–132 (2009).
  • Olazarán J, Reisberg B, Clare L et al. Nonpharmacological therapies in Alzheimer’s disease: a systematic review of efficacy. Dement. Geriatr. Cogn. Disord.30(2), 161–178 (2010).
  • Vernooij-Dassen M, Vasse E, Zuidema S, Cohen-Mansfield J, Moyle W. Psychosocial interventions for dementia patients in long-term care. Int. Psychogeriatrics22(7), 1121–1128 (2010).
  • Van Mierlo LD, Van der Roest HG, Meiland FJM, Dröes RM. Personalized dementia care; proven effectiveness of psychosocial interventions in subgroups. Ageing Res. Rev. (2), 163–183 (2010).
  • Cantegreil-Kallen I, De Rotrou J, Rigaud AS. Cognitive stimulation for people with mild cognitive impairment and early dementia. In: Early Psychosocial Interventions in Dementia. Moniz-Cook E, Manthorpe J (Eds). Jessica Kingsley Publishers, London, UK, 81–92 (2009).
  • Spector A, Davies S, Woods B, Orrell M. Can reality orientation be rehabilitated? Development and piloting of an evidence-based programme of cognition-based therapies for people with dementia. Neuropsychol. Rehabil.11, 377–397 (2001).
  • Yu F, Rose KM, Burgener SC et al. Cognitive training for early-stage Alzheimer’s disease and dementia. J. Geront. Nurs.35(3), 23–29 (2009).
  • Wilson BA. Cognitive rehabilitation: how it is and how it might be. J. Int. Neuropsychol. Soc.3, 487–496 (1997).
  • Clare L, Linden DE, Woods RT et al. Goal-oriented cognitive rehabilitation for people with early-stage Alzheimer disease: a single-blind randomized controlled trial of clinical efficacy. Am. J. Geriatric Psychiatry18(10), 928–939 (2010).
  • Clare L. Working with memory problems. In: Early Psychosocial Interventions in Dementia. Moniz-Cook E, Manthorpe J (Eds). Jessica Kingsley Publishers, London, UK, 73–80 (2009).
  • Kessels RP, Remmerswaal M, Wilson BA. assessment of nondeclarative learning in severe Alzheimer dementia: the Implicit Memory Test (IMT). Alzheimer Dis. Assoc. Disord.25(2), 179–183 (2011).
  • Clare L, Wilson A, Breen K, Hodges JR. Errorless learning of face-name associations in early Alzheimer’s disease. Neurocase5, 37–46 (1999).
  • Quayhagen MP, Quayhagen M. Differential effects of family based strategies on Alzheimer’s disease. Gerontologist29, 150–155 (1989).
  • Sandman CA. Memory rehabilitation in Alzheimer’s disease: preliminary findings. Clin. Gerontol.13, 19–33 (1993).
  • Moniz-Cook E, Agar S, Gibson G, Win T, Wang M. A preliminary study of the effects of early intervention with people with dementia and their families in a memory clinic. Aging Ment. Health2, 199–211 (1998).
  • Tárraga L, Boada M, Modinos G et al. A randomised pilot study to assess the efficacy of an interactive, multimedia tool of cognitive stimulation in Alzheimer’s disease. J. Neurol. Neurosurg. Psychiatry77, 1116–1121 (2006).
  • Franco M, Jones K, Woods B, Gomez P. Gradior; a personalised computer-based cognitive training programme for early intervention in dementia. In: Early Psychosocial Interventions in Dementia. Moniz-Cook E, Manthorpe J (Eds). Jessica Kingsley Publishers, London, UK, 93–105 (2009).
  • Clare L, Wilson BA, Carter G, Breen K, Gosses A, Hodges JR. Intervening with everyday memory problems in dementia of Alzheimer type: an errorless learning approach. J. Clin. Exp. Neuropsychol.22(1), 132–146 (2000).
  • Loewenstein DA, Acevedo A, Czaja SJ, Duara R. Cognitive rehabilitation of mildly impaired Alzheimer disease patients on cholinesterase inhibitors. Am. J. Geriatr. Psychiatry12(4), 395–402 (2004).
  • Quayhagen MP, Quayhagen M. Testing of a cognitive stimulation intervention for dementia caregiving dyads. Neuropsychol. Rehabil.11, 319–332 (2001).
  • Zanetti O, Zanieri G, Giovanni G et al. Effectiveness of procedural memory stimulation in mild Alzheimer’s disease patients: a controlled study. Neuropsychol. Rehabil.11, 263–272 (2001).
  • Davis RN, Massman PJ, Doody RS. Cognitive intervention in Alzheimer disease: a randomized placebo-controlled study. Alzheimer Dis. Assoc. Disord.15(1), 1–9 (2001).
  • Spector A, Orrell M, Davies S, Woods B. Reality orientation for dementia. Cochrane Database Syst. Rev.4, CD001119 (2000b).
  • Metitieri T, Zanetti O, Geroldi C et al. Reality orientation therapy to delay outcomes of progression in patients with dementia. A retrospective study. Clin. Rehabil.15, 471–478 (2001).
  • Cahn-Weiner DA, Malloy PF, Rebok GW, Ott BR. Results of a randomized placebo-controlled study of memory training for mildly impaired Alzheimer’s disease patients. Appl. Neuropsychol.10(4), 215–223 (2003).
  • Giordano M, Domingues LJ, Vitrano T et al. Combination of intensive cognitive rehabilitation and denepezil therapy in Alzheimer’s disease (AD). Arch. Gerontol. Geriatr.51(3), 245–249 (2010).
  • Grandmaison E, Simard M. A critical review of memory stimulation programs in Alzheimer’s Disease. J. Neuropsychiatry Clin. Neurosci.15, 130–144 (2003).
  • Sitzer DI, Twamley EW, Jeste DV. Cognitive training in Alzheimer’s disease: a meta-analysis of the literature. Acta Psychiatr. Scand.114(2), 75–90 (2006).
  • Mate-Kole CC, Fellows RP, Said PC et al. Use of computer assisted and interactive cognitive training programmes with moderate to severely demented individuals: a preliminary study. Aging Ment. Health11(5), 485–495 (2007).
  • Spector A, Thorgrimsen L, Woods B et al. Efficacy of an evidence-based cognitive stimulation therapy programme for people with dementia: randomised controlled trial. Br. J. Psychiatry183, 248–254 (2003).
  • Orrell M. Cognitive stimulation therapy. Alzheimer Dis. Int.20(4), 11 (2010).
  • Woods B, Thorgrimsen L, Spector A, Royan L, Orrell M. Improved quality of life and cognitive stimulation therapy in dementia. Aging Ment. Health10(3), 219–226 (2006).
  • Knapp M, Thorgrimsen L, Patel A et al. Cognitive stimulation therapy for people with dementia: cost–effectiveness analysis. Br. J. Psychiatry188, 574–580 (2006).
  • Orrell M, Spector A, Thorgrimsen L, Woods B. A pilot study examining the effectiveness of maintenance cognitive stimulation therapy (MCST) for people with dementia. Int. J. Geriatr. Psychiatry20(5), 446–451 (2005).
  • Aguirre E, Spector A, Hoe J et al. Maintenance cognitive stimulation therapy (CST) for dementia: a single-blind, multicentre, randomized controlled trial of maintenance CST vs. CST for dementia. Trials11, 46 (2010).
  • De Rotrou J, Cantegreil-Kallen I, Cimetière C. [Evaluation of the memo-senior]. Report for the Fondation Nationale Gerontologie, France (2000).
  • Breuil V, De Rotrou J, Forette F, Tortrat D, Ganansia-Ganem A, Frambourt A. Cognitive stimulation of patients with dementia. Preliminary results. Int. J. Geriatr. Psychiatry9, 211–217 (1994).
  • Vidal JC, Lavieille-Letan S, Fleury A, De Rotrou J. [Cognitive and psychosocial stimulation of patients with dementia in institutions]. Revue Gériatr.23, 199–204 (1998).
  • Farina E, Mantovani F, Fioravanti R et al. Evaluating two group programmes of cognitive training in mild-to-moderate AD: is there any difference between a ‘global’ stimulation and a ‘cognitive-specific’ one? Aging Ment. Health10(3), 211–218 (2006).
  • Burnham M. Memory groups for people with early dementia. In: Early Psychosocial Interventions in Dementia. Moniz-Cook E, Manthorpe J (Eds). Jessica Kingsley Publishers, London, UK, 106–113 (2009).
  • Ermini-Fünfschilling D, Meier D. [Memory training: an important constituent of milieu therapy in senile dementia]. Z. Gerontol. Geriatr.28(3), 190–194 (1995).
  • Camp CJ, Foss JW, O’Hanlon AM, Stevens AB. Memory interventions for persons with dementia. Appl. Cogn. Psychol.10(3), 193–210 (1996).
  • Lipinska B, Backman L, Mantyla T, Viitanen M, Effectiveness of selfgenerated cues in early Alzheimer’s disease. J. Clin. Exp. Neuropsychol16, 809–819 (1994).
  • Dröes RM. Psychomotor group therapy for demented patients in the nursing home. In: Care-Giving in Dementia II. Miesen B, Jones G (Eds). Routledge, Abingdon, UK, 95–118 (1997).
  • Lange-Asschenfeldt C, Kojda G. Alzheimer’s disease, cerebrovascular dysfunction and the benefits of exercise: form vessels to neurons. Exp. Gerontol.43(6), 499–504 (2008).
  • Coelho FG, Santos-Galduroz RF, Gobbie S, Stella F. [Systematized physical activity and cognitive performance in elderly with Alzheimer’s dementia: a systematic review]. Rev. Bras. Psiquiatr.31(2), 163–170 (2009).
  • Blankevoort CG, Van Hheuvelen MJ, Boersma F, Luning H, De Jong J, Scherder EJ. Review of effects of physical activity on strength, balance, mobility and ADL performance in elderly subjects with dementia. Dement. Geriatr. Cogn. Disord.30(5), 392–402 (2010).
  • Van de Winkel A, Feys H, De Weerdt W, Dom R. Cognitive and behavioural effects of music-based exercises in patients with dementia. Clin. Rehabil.18(3), 253–260 (2004).
  • Yáguez L, Shaw KN, Morris R, Matthews D. The effects on cognitive functions of a movement-based intervention in patients with Alzheimer’s type dementia: a pilot study. Int. J. Geriatr. Psychiatry26(2), 173–81 (2011).
  • Diesfeldt HFA, Diesfeldt-Groenendijk H. Improving cognitive performance in psychogeriatric patients: the influence of physical exercise. Age Ageing6, 58–64 (1977).
  • Molloy DW, Delaquerriere Richardson L, Grilly RG. The effects of a three-month exercise programme on neuropsychological function in elderly institutionalized woman: a randomised controlled trial. Age Ageing17, 303–310 (1988).
  • Alessi CA, Yoon EJ, Schnelle JF, Al-Samarrai NR, Cruise PA. A randomised trial of a combined physical activity and environmental intervention in nursing home residents: do sleep and agitation improve? J. Am. Geriatr. Soc.47, 748–791 (1999).
  • Williams CL, Tappen RM. Effect of exercise on mood in nursing home residents with Alzheimer’s disease. Am. J. Alzheimers Dis. Other Demen.22(5), 389–397 (2007).
  • Hopman-Rock M, Staats PGM, Tak ECPM, Dröes RM. The effects of a psychomotor activation programme for use in groups of cognitively impaired people in homes for the elderly. Int. J. Geriatr. Psychiatry14, 633–642 (1999).
  • Woods B, Spector AE, Jones CA, Orrell M, Davies SP. Reminiscence therapy for dementia. Cochrane Database Syst. Rev.2, CD001120 (2005).
  • Gibson F. What can reminiscence contribute to people with dementia? In: Reminiscence Reviewed: Evaluations, Archievements, Perspectives. Bornat J (Ed.). Open University Press, Buckingham, UK, 46–60 (1994).
  • Woods B, McKiernan F. Evaluating the impact of reminiscence on older people with dementia. In: The Art and Science of Reminiscing: Theory, Research, Methods and Applications. Haight Bk, Webster JD (Eds). Taylor and Francis, Washington DC, USA, 233–242 (1995).
  • Schweitser P. Remembering yesterday: a European perspective. J. Dementia Care7(1), 18–21 (1999).
  • Wang JJ. Group reminiscence therapy for cognitive and affective function of demented elderly in Taiwan. Int. J. Geriatr. Psychiatry22(12), 1235–1240 (2007).
  • Ito T, Meguro K, Akanuma K, Ishii H, Mori E. A randomized controlled trial of the group reminiscence approach in patients with vascular dementia. Dement. Geriatr. Cogn. Disord.24(1), 48–54 (2007).
  • Mills MA. Narrative identity and dementia: a study of emotion and narrative in older people with dementia. Ageing Soc.17, 673–698 (1997).
  • Woods RT, Bruce E, Edwards RT et al. Reminiscence groups for people with dementia and their family carers: pragmatic eight-centre randomised trial of joint reminiscence and maintenance versus usual treatment: a protocol. Trials10, 64 (2009).
  • Neal M, Barton Wright O. Validation therapy for dementia. Cochrane Database Syst. Rev.3, CD001395 (2005).
  • Forbes D, Culum I, Lischka AR et al. Light therapy for managing cognitive, sleep, functional, behavioural or psychiatric disturbances in dementia. Cochrane Database Syst. Rev.4, CD003946 (2009).
  • Orrell M, Woods B. Tacrine and psychological therapies in dementia – no contest? Editorial comment. Int. J. Geriatr. Psychiatry11, 189–192 (1996).
  • Moniz-Cook E, Vernooij-Dassen M, Woods B, Orrell M. Psychosocial interventions in dementia care research: the INTERDEM manifesto. Aging Ment. Health15(3), 283–290 (2011).
  • Moniz-Cook E, Vernooij-Dassen M, Woods R et al. For the Interdem group A European Consensus on outcome measures for psychosocial intervention research in dementia care. Aging Ment. Health12(1), 14–29 (2008).
  • Luengo-Fernandez R, Leal J, Gray A. Dementia 2010. The Prevalence, Economic Cost and Research Funding of Dementia Compared With Other Major Diseases. Alzheimer’s Research Trust, Cambridge, UK (2010).
  • Wimo A, Prince M. World Alzheimer Report 2010. The Global Economic Impact of Dementia. Alzheimer’s Disease International, London, UK (2010).
  • Voigt-Radloff S, Graff M, Leonhart R. WHEDA study: effectiveness of occupational therapy at home for older people with dementia and their caregivers – the design of a pragmatic randomised controlled trial evaluating a Dutch programme in seven German centres. BMC Geriatr.9, 44 (2009).

Websites

Memory problems in dementia: adaptation and coping strategies and psychosocial treatments

To obtain credit, you should first read the journal article. After reading the article, you should be able to answer the following, related, multiple-choice questions. To complete the questions (with a minimum 70% passing score) and earn continuing medical education (CME) credit, please go to http://www.medscape.org/journal/expertneurothera. Credit cannot be obtained for tests completed on paper, although you may use the worksheet below to keep a record of your answers. You must be a registered user on Medscape.org. If you are not registered on Medscape.org, please click on the New Users: Free Registration link on the left hand side of the website to register. Only one answer is correct for each question. Once you successfully answer all post-test questions you will be able to view and/or print your certificate. For questions regarding the content of this activity, contact the accredited provider, [email protected]. For technical assistance, contact [email protected]. American Medical Association’s Physician’s Recognition Award (AMA PRA) credits are accepted in the US as evidence of participation in CME activities. For further information on this award, please refer to http://www.ama-assn.org/ama/pub/category/2922.html. The AMA has determined that physicians not licensed in the US who participate in this CME activity are eligible for AMA PRA Category 1 Credits™. Through agreements that the AMA has made with agencies in some countries, AMA PRA credit may be acceptable as evidence of participation in CME activities. If you are not licensed in the US, please complete the questions online, print the AMA PRA CME credit certificate and present it to your national medical association for review.

Activity Evaluation: Where 1 is strongly disagree and 5 is strongly agree

1. Your patient is a 73-year-old woman with early Alzheimer disease. Based on the review by Prof. Dröes and colleagues, which of the following statements about memory problems in people with dementia, their impact on everyday life, and coping strategies is most likely correct?

  • A In early stages, language impairment is likely to be more prominent than memory problems

  • B The vast majority of people with dementia experience memory problems and other dementia-related problems in the same way

  • C People with dementia do not face adaptive tasks experienced in chronic disease in general

  • D Coping strategies used by people with dementia may include denial, overcompensation, downplaying, regression, avoiding problems and social contact, and humor

2. You are considering psychosocial treatments for the patient described in question 1. Based on the review by Prof. Dröes and colleagues, which of the following statements about these treatments is most likely correct?

  • A Psychosocial treatments are significantly less effective than currently available anti-Alzheimer drugs

  • B Cognitive rehabilitation builds on the memory skills a person still has and uses compensatory aids when memory fails

  • C Psychosocial treatments have been clearly proven to improve cognition

  • D There is no evidence to support use of movement activation therapy

3. You are considering pharmacotherapy for the patient described in question 1. Based on the review by Prof. Dröes and colleagues, which of the following statements about available drugs is most likely correct?

  • A No available pharmacotherapy can stabilize progression of cognitive decline, even for a short while

  • B Rivastigmine is an NMDA-antagonist

  • C Donepezil has more side effects than rivastigmine tablets

  • D Psychosocial treatment may offer an additional benefit to patients taking anti-Alzheimer medication

Notes

Modified with permission from Citation[12].

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.