Lung microRNA: from development to disease

Abstract

Recent evidence demonstrates the importance of microRNAs (miRNAs) in several human diseases, including solid and hematological malignancies, diabetes and diseases of the nervous system. However, little is known about the role that miRNAs play in the development and pathogenesis of lung diseases. Murine models of disease suggest that the loss of specific miRNAs is vital to lung development and modulation of the immune system that consequently results in the development of uncontrolled inflammation in the lung. Other studies have found that bacterial challenges also upregulate the expression of specific miRNAs. In this article, we will focus on miRNA involvement in lung development and the possibility that dysregulation and/or reactivation of miRNAs may contribute to lung disease. We will also review the role of miRNAs in the pathogenesis of specific diseases, such as lung cancer, sepsis and smoking-related lung disease.

Keywords::

• cancer
• COPD
• inflammation
• lung development
• miRNA

Acknowledgements

The authors would like to recognize the assistance of Tim Eubank on his assistance in figure preparation.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.