Evaluation of plasma adiponectin levels in young men with coronary artery disease

Abstract

Objective — In this study, we investigated the relation between plasma adiponectin levels and other risk factors in a young patient population.

Material and results — We enrolled consecutively 69 young patients (<45years) with coronary artery disease in the study group. The patient enrollment period was between February 2003 and November 2004.The control group consisted of 42 age- and sex-matched healthy subjects.Anthropometric, lipid and other variables including adiponectin, fasting glucose and plasma insulin levels were measured in all subjects. Appropriate statistical analyses were performed to determine the differences between the groups, the relation between adiponectin and other parameters and independent factors that predict CAD.

There was a statistically significant difference between the groups in terms of lipid parameters (triglycerides, total cholesterol, HDL and LDL cholesterol). Mean plasma adiponectin levels were significantly lower in the patients (P<0.05).Among the risk factors adiponectin had a significant negative association with the plasma triglyceride level (P<0.01). Logistic regression analysis revealed triglycerides and adiponectin as independent predictors of CAD.The areas under the ROC curves of adiponectin and triglycerides were not different (P>0.05).

Conclusion — We found a decreased plasma adiponectin level in young male patients with coronary artery disease. It may be a novel marker of atherosclerosis in young men.

Key Words:

• adiponectin
• coronary artery disease
• young man