4
Views
1
CrossRef citations to date
0
Altmetric
Articles

The relationship between early recanalization and serum NT-proBNP levels in patients with a first ST-segment elevation myocardial infarction treated with primary coronary angioplasty

, , , &
Pages 479-484 | Received 12 Mar 2007, Accepted 27 Jun 2007, Published online: 23 May 2017
 

Abstract

Objective — Primary coronary angioplasty (PCI) performed in the first hours after the onset of chest pain plays an important role in the prevention of death and heart failure after acute myocardial infarction (MI). Levels of circulating natriuretic peptides (BNP and NT-proBNP) reflect the severity of left ventricular (LV) dysfunction. The blood concentration of these peptides is increased in patients with MI. The aim of this study is to evaluate whether early PCI (< 3 hours) after onset of chest pain modulates NT-proBNP levels in patients with first ST-elevation acute MI.

Methods and results — Serum NT-proBNP levels were measured on hospital admission and 4 to 5 days post MI.Transthoracic echocardiography was performed on the 4th day after MI.We included 111 consecutive patients with first ST-elevation acute MI treated with PCI with stent implantation. In 55 patients (49.5%) PCI was performed within 3 hours after the onset of symptoms (the study group). Multivariate analysis revealed that only the time from the onset of chest pain to PCI and EF/WMI were independently associated with serum NT-proBNP > 105 pg/ml on admission. Only EF/WMI and evolution of non-Q myocardial infarction correlated with an NT-proBNP level > 388.5 pg/ml on discharge.

Conclusions — NT-proBNP concentration measured both on admission and 4 to 5 days after acute MI independently correlates with echocardiographic parameters of LV systolic function (EF and WMSI). One hour delay in PCI raises the risk of NT-proBNP level elevation on admission by 30%.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.