Considerations for Developing Mitochondrial Transplantation Techniques for Individualized Medicine

Tweetable abstract

Mitochondrial transplantation has been used to treat various diseases associated with mitochondrial dysfunction. Here, we highlight the considerations in quality control mechanisms that should be considered in the context of mitochondrial transplantation.

Keywords: :

• individualized medicine
• mitochondria diseases
• mitochondria transfer
• mitochondria transplantation

Author contributions

K Neikirk: literature review, writing – original draft preparation, writing – review and editing. DC Stephens: literature review, writing – original draft preparation, writing – review and editing. AG Marshall: literature review, writing - review and editing. JA Gaddy: literature review, writing – review and editing. SM Damo: literature review, writing – review and editing. A Hinton Jr: funding, conceptualization, supervision, writing – review and editing.

Financial disclosure

The UNCF/Bristol-Myers Squibb EE. Just Faculty Fund, Career Award at the Scientific Interface (CASI Award) from Burroughs Welcome Fund (BWF) ID no. 1021868.01, BWF Ad-hoc Award, NIH Small Research Pilot Subaward to 5R25HL106365-12 from the National Institutes of Health PRIDE Program, DK020593, Vanderbilt Diabetes and Research Training Center for DRTC, CZI Science Diversity Leadership grant number 2022-253529 from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation (to A Hinton Jr). NSF EES2112556, NSF EES1817282, NSF MCB1955975 and CZI Science Diversity Leadership grant no. 2022-253614 from the Chan Zuckerberg Initiative DAF, an advised fund of Silicon Valley Community Foundation (to SM Damo). The funder had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

Competing interests disclosure

The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, stock ownership or options and expert testimony.

Writing disclosure

No writing assistance was utilized in the production of this manuscript.