The Role of Guggulsterone on the NF-κB Pathway in Inflammatory Bowel Disease: Preclinical Evidence

Abstract

Guggulsterone, a phytosterol in the herb Commiphora wightii (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-κB, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.

Keywords:

• bioactive compounds
• cytokines
• dextran sodium sulfate
• guggulsterone
• inflammatory bowel disease
• intestinal epithelial cells
• NF-κB
• preclinical studies
• ulcerative colitis

Author contributions

S Sarvesh, SK Sujitha Priyaka and RC Satish Kumar: Methodology. S Sarvesh, SK SujithaPriyaka and A Jha: Writing. S Sarvesh: Conceptualization.

Acknowledgments

The authors would like to thank all the health care professionals involved.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Availability of data and materials

All data and materials generated are included in this published article and are available upon reasonable request.