Prognostic Significance of the angiopoietin-2 for Early Prediction of Septic Shock in Severe Sepsis Patients

Abstract

Aim: The current study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis. Methods: Angiopoietin-1 and -2 levels were quantified in plasma from 105 patients with severe sepsis by ELISA. Results: Angiopoietin-2 levels elevated according to the severity of sepsis progression. Angiopoietin-2 levels were correlated with mean arterial pressure and platelets counts, total bilirubin, creatinine, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis with an AUC = 0.97 and septic shock from severe sepsis patients (AUC = 0.778). Conclusion: Plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.

Plain Language Summary

The study investigated the plasma levels of angiopoietin-1/-2 and their association with clinical outcomes of sepsis in plasma from 105 patients with severe sepsis by ELISA. The results showed that angiopoietin-2 levels elevated according to the severity of sepsis progression and were correlated with important clinical parameters such as mean arterial pressure and platelets counts, procalcitonin, lactate levels and SOFA score. Angiopoietin-2 levels accurately discriminated for sepsis and septic shock. Thus, plasma angiopoietin-2 levels may serve as an additional biomarker for severe sepsis and septic shock.

Keywords:

• angiopoietin-1
• angiopoietin-2
• biomarker
• sepsis
• septic shock

Supplementary data

To view the supplementary data that accompany this paper please visit the journal website at:www.tandfonline.com/doi/full/10.2217/epi-2016-0184

Author contributions

LT Thanh Duyen, BVM and HVQ recruited study subjects, collected samples and clinical data, contributed materials and reagents. TT Phuong Thao, LV Khanh, BN Linh Trang, NT Giang and NT Hang performed the experiments. NT Viet, CV Mao and NL Toan contributed to study design and revised the manuscript. HV Tong designed, supervised the study, contributed materials and reagents, carried out the statistical analyses, interpreted data and wrote the manuscript. All authors agreed with the results and conclusions.

Acknowledgments

The authors thank all study subjects for their participation and acknowledge the medical staff at the Viet Tiep hospital for their clinical support.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Ethical conduct of research

Informed written consent was obtained from all study participants after they were explained in detail about the study and before recruitment and sampling. All clinical procedures were performed in accordance with relevant guidelines and regulations. The study was approved by the Ethical Committee, Viet Tiep Hospital, Hai Phong, Vietnam.