Human herpesvirus-7 Meningitis in an Immunocompetent Adult Patient: a Case Report

Abstract

Aim: The underlying pathological mechanisms of CNS human herpesvirus-7 (HHV-7) related infections are still unknown, especially among immunocompetent adults. Although HHV-7 meningitis in immunocompetent adults is usually uncommon, serious consideration for possible HHV-7 involvement should be taken when assessing CNS infection of unknown etiology. Case presentation: We report a 53-year-old female who presented for fever and progressive headaches. Cerebrospinal fluid (CSF) analysis was compatible with a viral meningitis. CSF cultures were negative and HHV-7 DNA was the only strain detected in the CSF analysis. The patient died 1 month later following complications and cardiac arrest. Conclusion: HHV-7 CNS infection in immunocompetent patient can be a serious infection. Prompt diagnosis and treatment management are essential for better outcome.

Plain Language Summary

We do not fully understand how human herpesvirus-7 (HHV-7) brain infections affect healthy individuals. We share a case of a 53-year-old woman who presented with fever and worsening headaches. In her cerebrospinal fluid analysis, only HHV-7 DNA was found. She received treatment with acyclovir initially and later with ganciclovir for a total of 4 weeks. Unfortunately, the patient passed away 1 month later due to complications and cardiac arrest. We highlight the need for robust guidelines for effectively treating HHV-7 brain infections in healthy individuals.

Tweetable abstract

Human herpesvirus-7 brain infection can lead to death in immunocompetent adults, a new report has found.

Keywords:

• HHV-7
• immunocompetent adult
• meningitis

Author contributions

M Matar made substantial contribution to conception, interpretation of data and substantially revised the manuscript. R Fares wrote the paper. The authors read and approved the final manuscript.

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.

Informed consent disclosure

Written informed consent was obtained from the patient's husband for publication of this case report and any accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.