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Abstract
Aim: This study endeavors to explore the anti-arthritic effects of macerated oil derived from the plant's aerial parts. Methods: The macerated oil was prepared using maceration in coconut oil, and its phytochemical composition was elucidated using GC-MS. To assess its anti-arthritic activity, in-vitro studies were conducted using various assays. Results & conclusion: The macerated oil showed better antioxidant and anti-arthritic potential by in-vitro investigations. Molecular docking studies elucidated potential binding interactions between specific constituents of the oil and critical molecular targets implicated in the pathogenesis of arthritis, further substantiating its therapeutic potential. The results demonstrated that Abrus precatorius macerated oil could ameliorate arthritis severity in a dose-dependent manner.
Plain language summary
The study explores whether the oil from the Abrus precatorius plant can help people with arthritis. Arthritis is a painful condition that causes swelling and stiffness in the joints. Researchers are curious if this plant oil can ease the pain and reduce inflammation associated with arthritis. They are conducting experiments to see if it works and is safe to use. In the research, we study the effects of this plant oil on arthritis symptoms. This oil is obtained by soaking Abrus precatorius plant parts in coconut oil. Our results could offer a new and natural way to alleviate arthritis symptoms for those who suffer from it. This would be a significant finding as it might provide a less invasive and potentially more accessible option for managing arthritis discomfort. However, it is important to remember that more research is needed to ensure the oil is both effective and safe for arthritis relief.
Arthritis is a prevalent and debilitating global issue, causing pain, disability and reduced quality of life.
Effective and safe arthritis treatments remain a significant challenge.
This study explores the potential of macerated oil from the Abrus precatorius plant as a novel arthritis therapeutic agent.
The macerated oil was created by soaking the plant's aerial parts in coconut oil.
Gas chromatography-mass spectrometry (GC-MS) was used to analyze the chemical composition of the oil.
In-vitro studies were conducted to evaluate the oil's anti-arthritic properties using relevant experimental models.
Molecular docking studies identified potential interactions between oil components and molecular targets linked to arthritis development.
The study's results demonstrated that Abrus precatorius macerated oil effectively reduced arthritis severity in a dose-dependent manner.
This suggests the oil's potential as a safe and efficient treatment for arthritis, offering hope for better arthritis management.
Further research and clinical trials are required to confirm and fully validate the therapeutic benefits of this plant-derived oil.
Author contributions
S Vijayan drafted the work and revised it critically for important intellectual content; made substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data used in the work. T Margesan made substantial contributions to the conception or design of the work; or the acquisition, analysis or interpretation of data used in the work and approved the version to be published and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Financial disclosure
The authors have no financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Competing interests disclosure
The authors have no competing interests or relevant affiliations with any organization or entity with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Writing disclosure
No writing assistance was utilized in the production of this manuscript.
Acknowledgments
The authors would like to thank the management of SRM College of Pharmacy, SRM Institute of Science and Technology in extending their support in completion of this work.