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Abstract
Background
Breast cancer and thyroid cancer are two prevalent malignancies in women, and a potential association between the two diseases has been suggested.
Methods
This retrospective case-control study was conducted involving 97 patients with breast cancer and thyroid cancer (BC-TC group) and 97 age-matched patients with breast cancer alone (BC group). Thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free triiodothyronine (FT3), free thyroxine (FT4) and thyroid-stimulating hormone (TSH), were analyzed in healthy controls, BC patients, and BC-TC patients.
Results
BC-TC patients exhibited a higher rate of estrogen receptor (ER) and progesterone receptor (PR) positivity compared to BC patients. Serum T3 levels were significantly decreased in BC and BC-TC patients compared to healthy controls. However, there was no significant difference in T3 levels between BC and BC-TC patients. Serum TSH levels were significantly higher in BC-TC patients compared to BC patients.
Conclusion
ER positivity, PR positivity, and serum TSH levels greater than 4.45 mU/L were independent risk factors for primary thyroid cancer in breast cancer patients.
Data Sharing Statement
The raw data will be made available upon reasonable request to the corresponding author (Jie Li).
Ethical Approval
Cangzhou Central Hospital approved this study, and written informed consent was obtained from the participants. The study was performed in strict accordance with the Declaration of Helsinki, Ethical Principles for Medical Research Involving Human Subjects.
Consent for Publication
Not applicable.
Disclosure
The authors declare that they have no conflict of interest.