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Abstract
With about 22,000 new cases estimated in 2012 in the US and 15,500 related deaths, ovarian cancer is a heterogeneous and aggressive disease. Even though most of patients are sensitive to chemotherapy treatment following surgery, recurring disease is almost always lethal, and only about 30% of the women affected will be cured. Thanks to a better understanding of the molecular mechanisms underlying ovarian cancer malignancy, new therapeutic options with molecular-targeted agents have become available. This review discusses the rationale behind molecular-targeted therapies and examines how newly identified molecular targets may enhance personalized therapies for ovarian cancer patients.
Disclosure
The author reports no conflicts of interest in this work. This review was prepared by the author in her personal capacity. Ongoing clinical trials were found using the http://www.clinicaltrials.gov and http://www.clinicaltrials.com websites, as well as Internet searches. The opinions expressed in this article are the author’s own and do not necessarily reflect the views of any institutions and/or governments.