Using Monoclonal Antibody Therapies for Multiple Sclerosis: A Review

Abstract

Monoclonal antibody therapies have secured an important role in the therapeutic landscape for the treatment of both relapsing and progressive forms of multiple sclerosis due to their potent efficacy, convenient dosing schedules, and well-defined side effect profiles. Each therapy has unique risks and benefits associated with its specific mechanism of action which ultimately guides clinical decision-making for individual patients. This review will summarize the mechanisms of action, evidence leading to their approval, and clinically relevant considerations for each of the current monoclonal antibody therapies approved for the treatment of multiple sclerosis.

Keywords:

• monoclonal antibodies
• multiple sclerosis
• relapsing
• progressive
• review

Disclosure

Dr. Elsbernd has no conflicts of interests or financial disclosures to declare regarding this submission. This case report was prepared primarily by a physician while in the employment of the US Federal government. The views expressed herein are those of the authors and do not reflect the official policy or position of the Department of the Air Force, Department of Defense, or the US Government. Dr. Carter has received research support to Mayo Clinic from Genentech, Roche, Atara, and MedDay Pharmaceuticals.

Additional information

Funding

No funding was utilized in the creation of this review.