Acrodermatitis Continua of Hallopeau Evolving into Generalized Pustular Psoriasis Following COVID‐19: A Case Report of a Successful Treatment with Infliximab in Combination with Acitretin

Abstract

The global pandemic of coronavirus disease 2019 (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is emerging. Various cutaneous manifestations have been observed in patients with SARS-CoV-2 infection, yet exacerbations of psoriasis have been reported sporadically. Acrodermatitis continua of Hallopeau (ACH) is an uncommon, sterile pustular dermatosis involving one or more digits. In some rare cases, ACH may evolve into generalized pustular psoriasis (GPP), which is a severe, and potentially life-threatening, form of psoriasis that manifests itself with widespread eruptions of pustules. We describe the first case of a patient in whom ACH abruptly progressed into GPP during COVID-19. A combination of infliximab and acitretin was used allowing swift clinical improvement.

Keywords:

• psoriasis
• pustular psoriasis
• biologics
• biologic therapy
• SARS-CoV-2
• coronavirus

Ethical Considerations

Written informed consent has been provided by the patient to have the case details and accompanying images published. No institutional approval was required to publish the case details.

Acknowledgments

The authors would like to sincerely thank our patient for her cooperation.

Disclosure

No funding was received for this manuscript. The authors declare no conflicts of interest in this work.