Successful Treatment of a Patient with Pyoderma Gangrenosum, Plaque Psoriasis and Palmoplantar Pustulosis with Adalimumab

Abstract

Pyoderma gangrenosum (PG) is a rare autoinflammatory skin disorder, which is characterised by rapidly developing and tender cutaneous ulcers. The treatment of PG is challenging. Palmoplantar pustulosis (PPP) is also an autoinflammatory dermatosis with sterile pustules on the palms and/or the soles. We demonstrated a 68-year-old patient with coexisting autoinflammatory diseases including PG, 1-year history of plaque psoriasis and PPP, recovered after treatment with adalimumab. We also reviewed published reports of PG-associated autoinflammatory syndromes with adalimumab.

Keywords:

• adalimumab
• autoinflammatory syndrome
• palmoplantar pustulosis
• plaque psoriasis
• pyoderma gangrenosum

Consent for Publication

Informed consent for publication of the case details and connected images was gained from the patient. Institutional approval from the Ethics Committee of the First Affiliated Hospital, Zhejiang University School of Medicine has been obtained to publish the case details (Approved number: IIT-2022-004).

Disclosure

The authors report no conflicts of interest.

Additional information

Funding

National Natural Science Foundation of China (82173400 to JQ, 81972931 to HF), the Medical and Health Science and Technology Project of Health Commission of Zhejiang Province (2020KY558 to JQ).