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Review

The role of brimonidine tartrate gel in the treatment of rosacea

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Pages 529-538 | Published online: 23 Oct 2015
 

Abstract

Rosacea is a chronic cutaneous condition with a prevalence rate ranging from 9.6% to 22% in recent studies. Facial erythema (transient and permanent) is considered a common denominator that is frequently observed in all subtypes of rosacea and is estimated to affect more than 40 million people worldwide. Brimonidine tartrate is a selective α2-adrenergic receptor agonist and is the first topical treatment approved for facial erythema of rosacea. Clinical trials have demonstrated that brimonidine tartrate provided significantly greater efficacy, compared to vehicle, for the treatment of moderate to severe erythema of rosacea. In addition, brimonidine tartrate has demonstrated a rapid onset of effect, duration of action throughout the day, and good safety profile in studies of up to 1 year. This review critically discusses the role of brimonidine tartrate for the treatment of facial erythema of rosacea by examining both clinical study data and real-world dermatologist experiences across a wide spectrum of treated patients, and concludes that it is a significant therapeutic option in the management of an unmet need of this chronic condition.

Acknowledgments

Medical writing support was provided by Natasha Singh Kent, PhD; Gavin Kenny, PhD; and Jen Lewis, PhD, at Havas Life Medicom and was funded by Galderma. The studies were sponsored by Galderma R&D.

Disclosure

Doctors Jackson, Johnson, and Belasco have served as investigators and advisors for Galderma and participated in meetings as speakers for Galderma. Doctor Minni has participated as a speaker for Galderma, AbbVie, Allergan, Johnson and Johnson, Promius, and Valeant. The authors report no other conflicts of interest in this work.