Successful use of a topical mixture with ozolipoile in the treatment of actinic ulcers

Abstract

Purpose

Post-radiation skin damage is the result of alterations produced in the irradiated zone. There are different studies aimed at verifying the effectiveness of several kinds of molecules in the treatment of radiation-induced skin damage. The purpose of this study is to test a mixture with a formulation containing several natural active ingredients on actinic ulcers in patients receiving radiation therapies.

Patients and methods

The authors recruited 13 patients, and randomly divided them into a test group (T₁) and a control group (T₂). The patients in both groups were undergoing radiotherapy. The T₁ group was treated with a mixture called ozolipoile, whereas the T₂ group was administered hyaluronic acid gel followed by non-ablative laser therapy. We evaluated the obtained results, the time of clinical healing, the reduction of pain, and each side effect, comparing all data between the T₁ and T₂ groups.

Results

The average Visual Analog Scale results showed decrease in pain in both groups; however, while the T₁ group showed a significant decrease in the values, the T₂ group reported a more gradual reduction in the values, without ever reaching the minimum values obtained with the treatment with ozolipoile.

Conclusion

Treatment of actinic ulcers with ozolipoile mixture leads to faster control of pain and to better healing of small-size ulcers.

Keywords:

• actinic ulcers
• radiation-induced ulcers
• skin wound
• ozonide
• wound healing

Disclosure

The authors report no conflicts of interest in this work.