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Abstract
Purpose
We assessed the effect of home-based cognitive intervention (HCI) on cognitive function along with brain metabolism by 18F-FDG PET in patients with amnestic MCI (aMCI).
Patients and methods
Fifty-seven patients with aMCI from three hospitals were randomized (30 HCI, 27 control). For 12 weeks, subjects received HCI. Thirty-two subjects (15 HCI, 17 control) underwent brain 18-F-FDG-PET imaging at baseline and at 12 and 24 weeks.
Results
The HCI group showed significant improvement in the scores of the Controlled Oral Word Association Test (COWAT) 12 and at 24 weeks. Significant brain metabolic changes by 18F-FDG PET were not observed.
Conclusion
The current study suggests that HCI was effective in improving general cognition along with frontal executive function in patients with aMCI.
Acknowledgments
This study was supported by a grant from the Original Technology Research Program for Brain Science through the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) [2014M3C7A1064752] and Eisai Korea Inc. The abstract of this paper was presented at the Alzheimer’s Association International Conference (AAIC) in Chicago (July 22–26, 2018) as a poster presentation with interim findings. The poster’s abstract was published in “Poster Abstracts” in Alzheimer’s & Dementia.
Disclosure
The authors report no conflicts of interest in this work.