Recovery Of Bone And Muscle Mass In Patients With Chronic Kidney Disease And Iron Overload On Hemodialysis And Taking Combined Supplementation With Curcumin And Resveratrol

Abstract

Introduction

Malnutrition is common in haemodialysis patients and closely related to morbidity and mortality. We evaluated the effect of twelve weeks of supplementation with resveratrol and curcumin on recovery of bone and muscle mass and protein oxidation, lipid peroxidation on patients with chronic kidney disease and iron overload undergoing hemodialysis, we performed a randomized, double-blind, placebo-controlled trial.

Methods

We included a total of 40 patients, were randomly assigned to two groups, 20 to the group with antioxidant supplementation (Resveratrol + Curcumin) (Group A), treated with a daily oral dose of 500 mg of Resveratrol and 500 mg of Curcumin, and 20 to the control group treated with placebo (Group B).

Results

Significant differences were found in the body composition of the patients between both groups. There was a significant difference in Body Mass Index (BMI) values (p = 0.002), fat percentage (p = 0.007), muscle mass (p = 0.01) bone mass (p = 0.01), as well as in the score of the subjective global evaluation (p = 0.03). Also differences were found between the basal and final serum levels of Triglycerides (TG) (p = 0.01), VLDL (p = 0.003). A significant decrease in the levels of serum ferritin (2003.69 ± 518.73 vs 1795.65 ± 519.00 ng/mL; p = 0.04). Nor were significant differences observed between the baseline and the final Thiobarbituric Acid Reactive Substances (TBARS) values (70.45 ± 69.21 vs 50.19 ± 32.62, p = 0.24). The same results was obtained for carbonyl values (2.67 ± 0.75 vs 2.50 ± 0.85; p = 0.50).

Discussion

The present study is the first assay on patients with chronic kidney disease and iron overload that demonstrates the beneficial effects of combined supplementation with Curcumin and Resveratrol on muscle and bone mass. There was a significant decrease in circulating levels of ferritin, to finding that remarkably novel.

Keywords:

• curcumin
• resveratrol
• chronic kidney disease
• recovery of bone and muscle mass

Acknowledgements

This work was supported by Mexican grants from FIS/IMSS/1561.

Abbreviations

ALP, Alkaline Phosphatas; AMPK, AMP-activated protein kinase; AP-1, Activator protein; BAP, Bone alkaline phosphatase; BMI, Body Mass Index; CKD, Chronic Kidney Disease; FOXO, Forkhead box O; LS vBMD-trab, Trabecular Volumetric Bone Mineral Density of the Lumbar Spine; MuRF1, Muscle RING-finger protein-1; NAC, Antioxidant N-acetyl-L-Cysteine; NAD, Nicotine Adenine Dinucleotide; NF-KB, Nuclear factor -kB; PIF1, Proteolysis Inducing Factor; RANKL, Receptor Activator for Nuclear Factor κ B Ligand; ROS, Reactive Oxygen Species; RSV, Resveratrol; SGE, Subjective global evaluation; SIRT1, Sirtuin inhibitors; TBARS, Thiobarbituric Acid Reactive Substances; UPS, Ubiquitin Proteasome System.

Disclosure

The authors report no conflicts of interest in this work.