Glomerular Filtration Dysfunction is Associated with Cardiac Adverse Remodeling in Menopausal Diabetic Chinese Women

Abstract

Background

Previous studies have showed that nephropathy was associated with cardiac structural changes and dysfunction among diabetic adults. However, information on the association of glomerular filtration dysfunction with the cardiac adverse remodeling is still limited in menopausal diabetic women. Therefore, we investigated whether impaired glomerular filtration function is associated with the cardiac adverse remodeling in menopausal Chinese women with type 2 diabetes mellitus (DM).

Methods

A total of 1231 hospitalized menopausal Chinese women with type 2 DM were collected retrospectively. The cross-sectional data of echocardiography were compared among estimated glomerular filtration rate (eGFR) categorized groups.

Results

In menopausal diabetic women, moderate to severe glomerular filtration dysfunction (eGFR <60 mL/min per 1.73m²) was found to be associated with enlarged left-side atrioventricular chambers, increased ventricular wall thickness, decreased cardiac function and dilated right ventricle (All P < 0.05).

Conclusion

Glomerular filtration dysfunction is associated with cardiac adverse structural remodeling and dysfunction in menopausal Chinese women with type 2 DM.

Keywords:

• glomerular filtration rate
• type 2 diabetes mellitus
• cardiac remodeling
• menopausal women
• aging

Acknowledgments

This study was supported by the Natural Science Research Fund of the Medical Science & Technology Research Fund of Health Bureau of Chongqing City, China (No. 04-2-154 and No. 2009-2-290) and Chongqing Science & Technology Commission in Chongqing City, China (CSTC, No. 2007BB5276).

Disclosure

The authors report no conflicts of interest in this work.