Associations Between Estimated Pulse Wave Velocity and Five-Year All-Cause Mortality in Patients with Atherosclerotic Cardiovascular Disease with and without Standard Modifiable Risk Factors: Evidence From NHANES 1999-2016

Abstract

Aim

The study aimed to analyze the associations between estimated pulse wave velocity (ePWV) and 5-year mortality in atherosclerotic cardiovascular disease (ASCVD) patients with and without standard modifiable risk factors (SMuRFs), which included smoking status, hypertension, diabetes, and hypercholesterolemia.

Methods

The present retrospective cohort study utilized data from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2016. Patients with ASCVD who completed both the questionnaire survey and serum testing were included. Patients were categorized into the ≥1 SMuRF group if they had at least one SMuRF, while those without any SMuRFs were classified into the SMuRF-less group. The ePWV, which was calculated using the age and mean blood pressure, was evenly divided into three categories: low (Q1), medium (Q2), and high (Q3). Multivariable weighted Cox proportional-hazard regression analyses were utilized to explore the risk factors associated with 5-year mortality in patients with and without SMuRFs. And restricted cubic spline curve (RCS) was used to assess their nonlinear correlation.

Results

A total of 1901 patients with ASCVD were included in the study. For the patients in ≥1 SMuRF group, the Q3 group included patients who were older, with a higher proportion of males, more comorbidities, and a lower body mass index than the Q1 group (P<0.05). The Cox proportional-hazard regression model results revealed, the Q3 group had a higher risk of 5-year mortality than the Q1 group [hazard ratio (HR) 4.30, 95% confidence interval (CI) (2.66, 6.95), P<0.001]. RCS demonstrated a linear trend between high level of ePWV and decreased risks of mortality. Similar results were observed in the SMuRF-less group [HR 10.62, 95% CI (1.22, 92.06), P=0.032].

Conclusion

A high level of ePWV signified a higher risk of 5-year mortality in ASCVD patients with and without SMuRFs.

Keywords:

• atherosclerotic cardiovascular disease
• standard modifiable risk factors
• estimated pulse wave velocity
• all-cause mortality

Abbreviations

ePWV, estimated Pulse Wave Velocity; ASCVD, Atherosclerotic cardiovascular disease; SMuRFs, Standard modifiable risk factors; MBP, Mean blood pressure; HR, Hazard ratio; CI, Confidence interval; RCS, restricted cubic spline curve.

Data Sharing Statement

The datasets used and analyzed in the current study are available from the corresponding author upon reasonable request.

Ethics Approval and Consent to Participate

All NHANES protocols have received approval from the NCHS Ethics Committee (National Center for Health Statistics, 2012) and written informed consent has been obtained from all participants. This study was exempted from approval by the Institutional Review Board of 920th Hospital of Joint Logistics Support Force, PLA, as the use of deidentified and open access data does not constitute human subjects research.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

This study was supported by the Science and Technology Department of Yunnan Province (202101AY070001-030) and the 920th Hospital of Joint Logistics Support Force, PLA (2020YGD11).