RETRACTED ARTICLE: Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1

Abstract

Chen Z, Tao Q, Qiao B, Zhang L. Cancer Manag Res. 2019;11:6043‒6059.

The Editor and Publisher of Cancer Management and Research wish to retract the published article. Concerns were raised regarding the alleged duplication of regions found in images from Figure 7 and Figure 9. Specifically,

• Figure 7A, panel 48 h Blank appears to show duplicated regions.

• Figure 7A, panel 48 h NC appears to show duplicated regions.

• Figure 7A, panel 48 h siRNA-LINC01116 appears to show duplicated regions.

• Figure 7A, panel 48 h miR-136 inhibitor appears to show duplicated regions.

• Figure 7A, panel 48 h siRNA-LINC01116 + miR-136 inhibitor appears to show duplicated regions.

• Figure 7B, panel Blank and siRNA-LINC01116 + miR-136 inhibitor appears to show duplicated regions.

• Figure 7B, panel miR-136 mimic and Figure 7F, panel siRNA-LINC01116 appears to show duplicated regions.

• Figure 7B panel siRNA-LINC01116 + miR-136 inhibitor and Figure 7F, panel Blank appears to show duplicated regions.

• Figure 9C, panel TSCCa siRNA-LINC01116 appears to show duplicated regions.

• Figure 9C, panel TSCCa miR-136 mimic appears to show duplicated regions.

• Figure 9C, panel TSCCa miR-136 inhibitor appears to show duplicated regions.

• Figure 9C, panel Tca83 miR-136 mimic appears to show duplicated regions.

• Figure 9C, panel Tca83 miR-136 inhibitor appears to show duplicated regions.

• Figure 9C, panel Tca83 siRNA-LINC01116 + miR-136 inhibitor appears to show duplicated regions.

The authors responded to our queries but were unable to provide a satisfactory explanation for the alleged duplication nor were they able to provide adequate original data for their study. The Editor requested to retract the article and the authors were notified of this.

We have been informed in our decision-making by our policy on publishing ethics and integrity and the COPE guidelines on retractions.

The retracted article will remain online to maintain the scholarly record, but it will be digitally watermarked on each page as “Retracted”.

Keywords:

• long non-coding RNA LINC01116
• fibronectin 1
• microRNA-136
• oral squamous cell carcinoma
• epithelial–mesenchymal transition
• lymph node metastasis

View retraction statement:

Silencing of LINC01116 Suppresses the Development of Oral Squamous Cell Carcinoma by up-Regulating microRNA-136 to Inhibit FN1 [Retraction]