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Abstract
Ovarian cancer is the most lethal gynecologic malignancy due to the late diagnoses at advanced stages, drug resistance and the high recurrence rate. Thus, there is an urgent need to develop new techniques to diagnose and monitor ovarian cancer patients. Fourier transform infrared (FTIR) spectroscopy has great potential in the diagnosis of this disease, as well as the real-time monitoring of cancer development and chemoresistance. As a noninvasive, simple and convenient technique, it can not only distinguish the molecular differences between normal and malignant tissues, but also be used to identify the characteristics of different types of ovarian cancer. FTIR spectroscopy is also widely used in monitoring cancer cells in response to antitumor drugs, distinguishing cells in different growth states, and identifying new synthetic drugs. In this paper, the applications of FTIR spectroscopy for ovarian cancer diagnosis and other works carried out so far are described in detail.
Abbreviations
FTIR, Fourier Transform Infrared; PARP, poly(ADP-ribose) polymerase; CA-125, serum Cancer Antigen 125; MRI, Magnetic Resonance Imaging; CT, Computed Tomography; BRCA1/BRCA2, breast cancer susceptibility gene 1/2; ATR-FTIR, attenuated total reflection Fourier-transform infrared; SR-FTIR, synchrotron radiation-based FTIR spectroscopy; HD, high definition; UHD, ultra-high definition; HPV, human papillomavirus; MET, metformin; FFPE, formalin-fixed, paraffin-embedded.
Data Sharing Statement
All data generated or analyzed during this study are included in this article.
Ethics Approval and Consent to Participate
Not applicable.
Consent for Publication
Not applicable.
Disclosure
The authors have no conflicts of interest.