Lateral Ventricular Meningiomas: Clinical Features, Radiological Findings and Long-Term Outcomes

Abstract

Purpose

Lateral ventricle meningioma (LVM) is a rare type of intracranial meningioma, which has been rarely studied. It has different clinical features, imaging features, and long-term results from other locations. This study investigated the epidemiology, clinical characteristics and prognosis of LVM and comprehensively describes its characteristics.

Methods

This article analyzes the LVMs that were diagnosed pathologically in West China hospital between January 1, 2009 and July 1 2020. Demographic information, imaging characteristics and prognostic factors are discussed. Data analysis was performed using SPSS 23.0 and R version 3.5.3.

Results

We collected 7202 meningiomas and 195 LVMs (136 females; median age, 46 years; range, 5–81 years) were included in this study. Gross total resection was completed in 189 patients. The OS rate was 93.8%, and the recurrence rate was 5.2%. Multivariate regression analysis showed that sex (P = 0.01) and tumor size (P = 0.018) were related to WHO grade. Postoperative KPS (P = 0.003) was associated with OS. WHO grade (P = 0.025), extent of tumor resection (P < 0.001), and hospital day (P=0.028) were associated with recurrence.

Conclusion

LVMs require long-term follow-up, individualized treatment, and follow-up strategies to be formulated according to the relevant risk factors.

Keywords:

• lateral ventricular meningiomas
• imaging features
• prognosis
• recurrence

Data Sharing Statement

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Ethics Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the ethics Committee of the West China hospital (No. 2020(990)).

Consent to Participate

Informed consent was obtained from all individual participants and the parents of all children included in the study.

Author Contributions

Haibo Teng: Conception and design, methodology and investigation, data analysis and interpretation, study supervision, and writing and review. Zhiyong Liu: Data collection, Data analysis and interpretation and writing and review. Ouying Yan: Data analysis and interpretation and writing and review. Wenbo He: Data analysis and interpretation and review. Danyang Jie and Yuanwei Qie: Data analysis and interpretation and review. Jianguo Xu: Conception and design, methodology and investigation, data analysis and interpretation, study supervision, and writing and review. All authors made substantial contributions to conception and design, acquisition of data, or analysis and interpretation of data; took part in drafting the article or revising it critically for important intellectual content; agreed to submit to the current journal; gave final approval of the version to be published; and agree to be accountable for all aspects of the work. Haibo Teng and Zhiyong Liu are co-first authors.

Disclosure

Authors have no conflict of interest to declare.