Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China

Abstract

Objective

Human papillomavirus (HPV) infection is the risk factor for cervical cancer. Consequently, HPV DNA testing is an essential method for cervical cancer screening. Yet, data on the prevalence and genotype distribution of HPV and cervical cytological among women in northern Jiangsu Province of China are very limited.

Materials and Methods

A total of 36,500 women were enrolled at the Department of Pathology of Jinhu County People’s Hospital between January 1, 2016 and December 31, 2019. HPV genotypes was performed using YanengBio^® Human Papillomavirus Genotyping Kit. Thin liquid cytology tests (TCT) were conducted, based on cytology conditions set by Bethesda in 2001.

Results

The overall prevalence of HPV infection was 28.95%; it was age-dependent; the number of infections was highest in the 40–49 age group. Six thousand three hundred eighty-two women (16.87%) were found to have a pure high-risk HPV infection, while 918 women (2.43%) were found to have a pure low-risk HPV infection. The 6 most predominant genotypes were HPV 52, 58, 16, 53, 56, and 33. Moreover, 8923 women (45.09%) were affected by ASCUS, 4531 (22.90%) by LSIL, 3726 (18.83%) by ASC-H, and 2610 (13.19%) by HSIL.

Conclusion

This study revealed a high burden of HPV infection among women in northern Jiangsu Province of China and identified the distribution of the prevalent top 6 HPV genotypes in this area, which can be used as a useful reference for future work.

Keywords:

• human papillomavirus
• prevalence and genotype distribution
• infection
• cervical cancer
• northern Jiangsu Province

View correction statement:

Genotype Distribution and Prevalence of Human Papillomavirus Infection in Women in Northern Jiangsu Province of China [Corrigendum]

Acknowledgments

The National Natural Science Foundation of China, Grant 81560088, supported this work.

Ethical Approval

All studies were done in compliance with the regulations and guidelines of Jinhu County People’s Hospital institutional and conducted according to the Helsinki and the IACUC guidelines. Informed consent was obtained from all individual participants included in the study. Patients under the age of 18 have signed an informed consent form with themselves and their parents, and have been informed of the relevant circumstances. They are all voluntary.

Disclosure

The authors declare that they have no conflicts of interest.