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Abstract
Esophageal cancer has high incidence and mortality rates and a low five-year survival rate of <15% owing to its strong capabilities of invasion, relapse and metastasis. The classic view holds that metastasis and diffusion is an advanced event during cancer progression, but recent studies show that distant diffusion of primary cancer cells may actually be an early event. Detection of circulating tumor cells (CTCs) in the circulation may indicate tumor spread, so CTCs are considered to be the key factor of metastatic cascade. In recent years, despite research progress on CTCs, there is a lack of systematic and important evidence to confirm the diagnostic, monitoring and prognostic values of CTCs in esophageal squamous cell carcinoma (ESCC). In this review, we clarify the relationship between CTC values and ESCC and provide more reliable evidence to improve the management and treatment of ESCC.
Acknowledgments
This work was supported by a grant-in-aid (2020SA00112) from the Jurong City livelihood science and technology project and supported by National Natural Science Foundation of China(82003228). Yujing Shi write this manuscript, the authors thank Xiaolin Ge for checking and reading this manuscript, Yumeng Zhang, Xiaoke Di and Mengyang Ju for search papers and chose the papers, Liang Liang for modify this paper.
Disclosure
The authors report no conflicts of interest in this work.