The Association of Inflammatory Related Markers with the Prognosis in Elderly Patients with Colorectal Cancer

Abstract

Background

Colorectal cancer (CRC) is a common malignancy, especially among older adults. Inflammation has been implicated in cancer progression, making inflammatory indices potential prognostic markers. This study aimed to evaluate the prognostic significance of the Glasgow prognostic score (GPS), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), lymphocyte/C-reactive protein ratio (LCR), and C-reactive protein/albumin ratio (CAR) in older adults with CRC.

Methods

This population-based, retrospective observational study included patients aged ≥ 65 years with colorectal adenocarcinoma who were admitted to Taichung Veterans General Hospital (Chiayi branch) between 2017 and 2022. Demographic and clinicopathological characteristics, and results of inflammatory indices were collected from medical records for all patients. Receiver operating characteristic (ROC) curve analyses were performed to determine the optimal cutoffs of the inflammatory indices in predicting overall mortality. Associations between the inflammatory indices, overall survival (OS) and progression-free survival (PFS) were determined using univariate and multivariable Cox proportional hazard regression analyses, with model performance evaluated using the C-index.

Results

Data of 106 patients were analyzed. After adjusting for confounders, GPS ≥1 (vs 0) significantly predicted poor OS (adjusted hazard ratio [aHR]: 3.80, 95% confidence interval [CI]: 1.30–11.10, p= 0.015, C-index= 0.825) and PFS (aHR: 3.19, 95% CI: 1.34–7.57, p= 0.008, C-index= 0.785). CAR ≥1.0 (vs <1) significantly predicted poor OS (aHR: 2.36, 95% CI: 1.01–5.48), p=0.046, C-index= 0.825) and PFS (aHR: 2.33, 95% CI: 1.14–4.76, p= 0.020, C-index= 0.786).

Conclusion

Among hospitalized older adults with CRC in Taiwan, high GPS and CAR, but not NLR, PLR or LCR, are potentially useful prognostic indicators for poor OS and PFS.

Keywords:

• Colorectal cancer
• CRC
• prognosis
• mortality
• inflammation index
• Taiwan

Data Sharing Statement

Data are available from corresponding author upon reasonable request.

Ethics Approval and Informed Consent

The study protocol was approved by the Institutional Review Board (IRB) of Taichung Veterans General Hospital and complies with the Declaration of Helsinki. All written inform consents were obtained from each patient.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The author has declared that no competing interests exist.

Additional information

Funding

There is no funding to report.