Determinants of each domain of the Short Physical Performance Battery in COPD

Abstract

Background

The Short Physical Performance Battery (SPPB) is an assessment tool with good prognostic value in COPD. It includes the following: standing balance, 4 m gait speed test (4MGS), and the timed five-repetition sit-to-stand test (5STS). The specific differences in determinants between these three tasks have not been adequately characterized in COPD patients. We aimed to identify health-related, functional, and psychological determinants of each SPPB test.

Methods

We conducted a cross-sectional analysis of 137 patients with stable COPD. Patients performed the SPPB, quadriceps muscle strength (QMS), exercise tolerance test (6-min walk test [6MWT]), and pulmonary function; and health-related and psychological factors, physical activity, the COPD assessment test (CAT), body mass index, age, and depression were assessed.

Results

Separate multivariable regression models predicting the 4MGS, 5STS, and balance test results described 31%, 39.1%, and 12.1% of the variance for each test, respectively. QMS was negatively associated with all three tests. The 6MWT was negatively associated with the 4MGS and 5STS. Depression and age were positively associated with 4MGS scores, whereas CAT and age were positively associated with 5STS scores.

Conclusion

The three SPPB tests did not provide equivalent information regarding a COPD patient’s status. The 5STS was associated with health status factors, while the 4MGS was associated with psychological factors.

Keywords:

• COPD
• muscle strength
• gait speed
• 6-min walk test
• depression

Acknowledgments

The authors wish to thank the patients and personnel of the hospital unit for their cooperation during the course of this study and the medical manager of AstraZeneca Pharmaceutical Spain, S.A. (Maite Pérez Hernández). The study was supported by AstraZeneca pharmaceutical Spain, S.A. Menarini and Pfizer.

Disclosure

The authors report no conflicts of interest in this work.