Differences in health care outcomes between postdischarge COPD patients treated with inhaled corticosteroid/long-acting β₂-agonist via dry-powder inhalers and pressurized metered-dose inhalers

Abstract

Purpose

The aim of this study was to examine real-world differences in health care resource use (HRU) and costs among COPD patients in the USA treated with a dry powder inhaler (DPI) or pressurized metered-dose inhaler (pMDI) following a COPD-related hospitalization.

Methods

This retrospective analysis used the Truven MarketScan^® databases. Eligibility criteria included 1) age ≥40 years, 2) COPD diagnosis, 3) inpatient admission with a diagnosis of COPD exacerbation, 4) inhaled corticosteroid (ICS)/long-acting β₂-agonist (LABA) prescription within 10 days of hospital discharge (index date), and 5) continuous enrollment for 12 months preindex and 90 days postindex. Outcomes included pre- and postindex HRU and costs. DPI and pMDI groups were compared on postindex outcomes via multivariate models controlling for demographic and baseline characteristics.

Results

The sample included 1,960 DPI and 1,086 pMDI ICS/LABA patients. During the preindex period, pMDI patients were significantly more likely to be prescribed a short-acting β-agonist, experienced more COPD exacerbation-related hospital days, and had a greater number of pulmonologist visits compared to DPI patients (P<0.05), all suggestive of greater disease severity. However, multivariate models revealed that pMDI patients incurred 10% lower all-cause postindex costs (predicted mean costs [2016 US dollars]: $2,673 vs $2,956) and 19% lower COPD-related costs (predicted mean costs: $138 vs $169; P<0.05). Additionally, pMDI patients were 28% less likely to experience a COPD exacerbation-related hospital readmission within 60 days postdischarge compared to the DPI patients (OR: 0.72, 95% CI: 0.52–0.99, P<0.05).

Conclusion

Despite greater COPD-related HRU and costs preceding index hospitalization, US patients using a pMDI after hospital discharge incurred significantly lower all-cause and COPD-related health care costs compared with those using a DPI, in addition to a decreased likelihood of a COPD exacerbation-related hospital readmission. Results suggest that inhaler device type may influence COPD outcomes and that COPD patients may derive greater clinical benefit from treatment delivered via pMDI vs DPI.

Keywords:

• COPD
• inhaler
• inhaled corticosteroid
• long-acting β₂-agonist
• utilization
• costs

Acknowledgments

Editorial support was provided by Jessamine P Winer-Jones, PhD, of IBM Watson Health, which was in accordance with Good Publication Practice (GPP3) guidelines and funded by AstraZeneca. This research was presented in part at the American Thoracic Society Annual International Conference, San Diego, CA, USA, May 18–23, 2018.

Disclosure

ETW and LAM are employed by AstraZeneca. KAE, MB, and JT are employed by IBM Watson Health as consultants and received funding from AstraZeneca to conduct this study. GTF is a paid consultant of AstraZeneca. All authors report no other conflicts of interest in this work.