Disability Retirement After First Admission with Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Danish Nationwide Registry Cohort Study Using a Retrospective Follow-Up Design

Abstract

Introduction

Many chronic obstructive pulmonary disease (COPD) patients below retirement age are outside the workforce. The existing knowledge about association between acute exacerbation of COPD (AECOPD) and disability retirement is limited.

Aim

The aim of this study is to explore disability retirement in COPD patients 3 years following first-ever AECOPD.

Methods

This retrospective registry-based follow-up cohort study design is based on nationwide Danish registry data. Patients admitted to the hospital for the first time between 1999 and 2017 with AECOPD and age between 35 and 59 years, active in the workforce, were included in the study. Socio-demographics, comorbidities and inhaled medication use were explored. COPD patients’ hazard ratio of disability retirement during 3-year follow-up was calculated. Cox regression was used to examine the effects of covariates on disability retirement.

Results

A total of 4032 patients were included in the study. During follow-up, 17.2% (692/4032) experienced disability retirement from the workforce. Factors associated with disability retirement were expressed as hazard ratio (95% confidence intervals): Higher age (ref. age 46–50: Age 51–55, 1.42, (1.12–1.81); age 56–59, 1.37 (1.08–1.74)); living alone (1.34 (1.14–1.56)); number of comorbidities for 1, 2, and 3 comorbidities (1.36 (1.14–1.62), 1.57 (1.19–2.07), 1.77 (1.20–2.60)); emphysema (2.01 (1.44–2.79)); depression (1.60 (1.12–2.28)); cardiac comorbidity (1.38 (1.07–1.78)); triple inhalation therapy (2.76 (2.20–3.47)); ICS + LAMA or ICS + LABA treatment (1.82 (1.48–2.23)); and ICS treatment (1.49 (1.17–1.90)). Higher educational level was associated with a significantly reduced risk of disability retirement, medium, short higher and long higher educational level, relative to low education level (0.78 (0.67–0.91), 0.63 (0.48–0.83) and 0.27 (0.12–0.60)).

Conclusion

Patients vulnerable to disability retirement are patients with markers of severe COPD, comorbidities, and social vulnerability.

Keywords:

• chronic obstructive pulmonary disease
• return to work
• early retirement
• comorbidities

Data Sharing Statement

Data are available from the respective registries, and access is granted by the data responsible institute (The Capital Region of Denmark). For inquiries about the data extracted contact corresponding author Peter A. Jacobsen.

Ethics Approval and Informed Consent Statement

Ethical approval is not needed in Denmark for retrospective registry studies according to the Scientifical Ethical Committees Act §14 section 2. Access to data was granted by the data responsible institute (The Capital Region of Denmark, project id: P2019-402) where informed consent is not required in accordance with the Data Protection Act §10.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

Dr Christian Torp-Pedersen reports grants from Bayer, grants from Novo Nordisk, during the conduct of the study. The authors report no other conflicts of interest in this work.

Additional information

Funding

This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.