Abstract
Purpose
This study aimed to reveal the association between the osteoporosis self-assessment tool for Asians (OSTA) and airflow limitation (AL) in post-menopausal Japanese women.
Participants and Methods
This cross-sectional study included 1580 participants undergoing a comprehensive health examination using spirometry and dual-energy X-ray absorptiometry. The OSTA was calculated by subtracting the age in years from the body weight (BW) in kilograms, and the result was multiplied by 0.2. The OSTA risk level was defined as low (>-1), moderate (−4 to −1), or high (<-4). AL was defined as forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.7. The association between the OSTA and AL was assessed using logistic regression analysis.
Results
The prevalence of AL was significantly higher in the high OSTA group (15.3%) than in the low OSTA group (3.1%) (p<0.001). In multiple linear regression analysis, the OSTA was independently associated with FEV1/FVC. In logistic regression models adjusted for smoking status, alcohol consumption, current use of medication for diabetes, hyperglycemia, rheumatoid arthritis, second-hand smoke, and ovary removal showed a significantly higher risk of AL (odds ratio: 5.48; 95% confidence interval: 2.90–10.37; p<0.001) in participants with OSTA high risk than in those with OSTA low risk.
Conclusion
These results suggest that the OSTA high risk indicates reduced BMD at the femoral neck and presence of AL in Japanese post-menopausal women aged ≥45 years.
Ethical Approval
This study was approved by the Human Ethics Committee of Kumamoto University (Number 84) and the Japanese Red Cross Kumamoto Health Care Center.
Acknowledgments
We would like to thank the Japanese Red Cross Kumamoto Health Care Center technicians for their excellent technical assistance. This paper has been uploaded to Research Square as a preprint: https://www.researchsquare.com/article/rs-3152769/v1.pdf.
Disclosure
The authors report no conflicts of interest in this work.