Should chest examination be reinstated in the early diagnosis of chronic obstructive pulmonary disease?

Abstract

Background

Although proven to be associated with bronchial obstruction, chest signs are not listed among cues that should prompt spirometry in the early diagnosis of chronic obstructive pulmonary disease (COPD) in established guidelines.

Aims

We aimed to explore how chest findings add to respiratory symptoms and a history of smoking in the diagnosis of COPD.

Methods

In a cross-sectional study, patients aged 40 years or older, previously diagnosed with either asthma or COPD in primary care, answered questionnaires and underwent physical chest examination and spirometry.

Results

Among the 375 patients included, 39.7% had forced expiratory volume in 1 second/forced vital capacity <0.7. Hyperresonance to percussion was the strongest predictor of COPD, with a sensitivity of 20.8, a specificity of 97.8, and likelihood ratio of 9.5. In multivariate logistic regression, where pack-years, shortness of breath, and chest findings were among the explanatory variables, three physical chest findings were independent predictors of COPD. Hyperresonance to percussion yielded the highest odds ratio (OR = 6.7), followed by diminished breath sounds (OR = 5.0), and thirdly wheezes (OR = 2.3). These three chest signs also gave significant diagnostic information when added to shortness of breath and pack-years in receiver operating-characteristic curve analysis.

Conclusion

We found that chest signs may add to respiratory symptoms and a history of smoking in the diagnosis of COPD, and we conclude that chest signs should be reinstated as cues to early diagnosis of COPD in patients 40 years or older.

Keywords:

• diagnosis
• COPD
• physical chest examination
• spirometry

Introduction

Spirometry is the recommended method for assessing lung function in patients with suspected chronic obstructive pulmonary disease (COPD).¹ Although spirometry testing is performed increasingly often and spirometers are about to become standard equipment at GPs’ offices in some countries, easy access does not apply to all. Also, lung-function assessment by spirometry testing is not only a question of availability. Even with a spirometer at hand, the GP has to select the right patients for this examination to be cost-effective.²

Spirometry screening has been proposed as a measure for early detection of COPD in smokers.^3,4 The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines recommend a somewhat different approach, suggesting that COPD should be considered and spirometry performed if the patient is older than 40 years, and one or more of the following is present: dyspnea, chronic cough or sputum production, history of exposure to risk factors (eg, tobacco smoking), or a family history of COPD.¹

Chest signs are not on this list of cues that should prompt spirometry in the early diagnosis of COPD, although several studies published between 1970 and 2002 have demonstrated associations between chest findings and bronchial obstruction.^5–11 This study aimed to clarify how chest signs are associated with bronchial obstruction and to what degree chest signs may add to respiratory symptoms and smoking history in the diagnosis of COPD.

Methods

Subjects

Patients were recruited from seven GP offices in Norway. Of 43,241 patients listed at these offices, 18,931 were aged ≥40 years. Among these, 1,784 subjects had been registered with a diagnosis of asthma or COPD by a GP within 5 years before the start of the study. A random sample of these (n = 1,111) were mailed an invitation to participate in our study, and 380 patients (34%) consented and were included. The patients were examined between April 2009 and March 2010. The examinations, carried out by a total of 20 GPs during a stable phase of the disease, included auscultation and percussion of the chest, questionnaires, and spirometry.¹² The study was approved by the Regional Committee for Medical and Health Research Ethics.

Chest examination

Percussion and auscultation were performed bilaterally, and the GPs carried out the examinations as usual. The findings were recorded in a form integrated in the medical record that assured complete recordings. The form also included several items on the participants’ obstructive disease, comorbidity, and medications. Notably, the GPs were not told that the diagnostic usefulness of chest findings was among the objectives of our study. Due to different practice routines, the chest examinations were carried out before spirometry in four of the GPs’ offices, and after spirometry in the remaining three.

Questionnaires

Each patient answered a clinical COPD questionnaire (CCQ),¹³ scoring their respiratory symptoms and limitations in daily activities on scales from 0 to 6. Scores on shortness of breath, cough, and sputum were included as variables in the present study (Table 1). Smoking habits in terms of quantity and duration were recorded in a separate questionnaire. Pack-years (the number of cigarettes smoked daily multiplied by the number of total years of smoking, divided by 20) were calculated for each patient. Sporadic smokers were registered with 0.5 pack-years.

Table 1 Questions on shortness of breath, cough, and phlegm in the clinical COPD questionnaire (CCQ)

On average, during the past week, how often did you feel:

1. Short of breath at rest?

2. Short of breath during physical activities?

In general, during the past week, how much of the time:

5. Did you cough?

6. Did you produce phlegm?

One score (0–6) for each question

0 = Never

1 = Hardly ever

2 = A few times

3 = Several times

4 = Many times

5 = A great many times

6 = Almost all the time

Abbreviation: COPD, chronic obstructive pulmonary disease.

Spirometry

Spirometry was carried out by trained health-care workers, who followed the guidelines of the European Respiratory Society/American Thoracic Society.¹⁴ The patients were seated during the examination, and did not wear a nose clip. They were told not to take their regular medications on the examination day. All offices used the Spirare SPS310 spirometer (Diagnostica, Oslo, Norway). Postbronchodilator spirometry was obtained 20 minutes after inhalation of 0.4 mg salbutamol. Norwegian reference values were applied.¹⁵

Statistical analyses

The main outcome in the analysis was postbronchodilator forced expiratory volume in 1 second (FEV₁)/forced vital capacity (FVC) < 0.7, which according to the GOLD criteria indicates a presence of COPD, although asthma may be the primary disease. A secondary outcome was postbronchodilator FEV₁% predicted <50 in addition to FEV₁/FVC < 0.7, indicating severe COPD (GOLD stage III–IV). The diagnostic properties of chest signs, symptoms, and pack-years with respect to COPD and severe COPD were evaluated by calculating sensitivity, specificity, predictive value, and likelihood ratio (LR). LRs with 95% confidence intervals were calculated using online software.¹⁶

Statistically significant predictors of COPD and severe COPD in bivariate analysis were entered into logistic regression models, with the two categories of reduced lung function as outcome variables. To account for clustering of data, we used mixed-effect two-level models with the patient as first level and the examining GP as second level. A backward stepwise method was applied, in which only significant variables (P < 0.05) were retained in the final models.

Added diagnostic value of independent predictors in the multivariable logistic regression was evaluated by receiver operating-characteristic (ROC) curve analysis. A first curve was constructed by computing the sensitivity and specificity of the CCQ score of the significant respiratory symptom, a second curve by adding pack-years graded into five categories to the symptom score, and a third curve by adding the score for chest findings, reflecting the odds ratios of these findings, to the symptom score and the pack-year score. SPSS (version 19; IBM, Armonk, NY, USA) and STATA (version 12.0; College Station, TX, USA; two-level logistic regression) were used in the statistical analyses. A 5% level of statistical significance was applied.

Sensitivity analyses

The GPs were not blinded for clinical information about the patients, and we checked whether chest examination after spirometry was associated with improved estimates of diagnostic value compared to chest examination before spirometry. Then we compared the sensitivity, specificity, and LRs of “any chest sign” obtained in practices where chest examination was carried out before spirometry with that obtained where chest examination was done after spirometry. In practices where chest examination was carried out before spirometry, we also checked whether the diagnostic values of “any chest sign” differed dependent on whether the evaluation was done against prebronchodilator spirometry or postbronchodilator spirometry.

Results

Of the 380 patients who took part in the study, two were excluded from analysis due to ongoing exacerbation and three due to missing data. The mean (± standard deviation) age of the 375 included patients was 61.4 ± 11.5 years, and 61.9% were women; 74.4% were current or previous smokers, and 39.1% had smoked ≥20 pack-years (Table 2). Mild or moderate COPD (GOLD I–II) was registered in 28.0%, and severe COPD (GOLD III–IV) in 11.7% of the subjects (Table 2). The most frequently reported respiratory symptoms were shortness of breath when doing physical activities and coughing (Table 2). At least one chest sign was recorded in 38.7% of the patients. Wheezes and diminished breath sounds were the chest signs most frequently recorded (Table 2). The frequency of heavy smoking, severe dyspnea, and chest signs all increased significantly by decreasing lung function (P < 0.001 for all variables, Figure 1).

Table 2 Sex, age, diagnosis, smoking history, lung function (by GOLD stages), respiratory symptoms, and chest signs in 375 patients aged ≥40 years diagnosed with asthma or COPD in primary care

	n	%
Sex
Men	143	38.1
Women	232	61.9
Age
<65 years	224	59.7
≥65 years	151	40.3
Diagnosis by General Practitioner (GP)
Only COPD	74	19.7
Only asthma	210	56.0
Both COPD and asthma	91	24.3
Smoking history
Never smoked	96	25.6
Smoking now	106	28.3
Previously smoked	173	46.1
Pack-yearsa
Never smoked	96	27.0
<10	45	12.7
10–20	75	21.1
≥20–40	102	28.7
≥40	37	10.4
Lung function
Normal spirometry/restriction	226	60.3
GOLD I	18	4.8
GOLD II	87	23.2
GOLD III or GOLD IV	44	11.7
Respiratory symptoms during the past week (from CCQ)
Short of breath at rest, several times or moreb	41	11.0
Short of breath doing physical activities, several times or morec	191	51.5
Short of breath doing physical activities, many times or mored	127	33.9
Short of breath doing physical activities, a great many times or moree	69	18.6
Cough, several times or moref	149	40.3
Phlegm, several times or moreg	134	35.7
Chest signs
Wheezes/rhonchi
Unilateral and/or bilateral	63	16.8
Bilateral	53	14.1
Crackles
Unilateral and/or bilateral	37	9.9
Bilateral	26	6.9
Diminished breath sounds
Unilateral and/or bilateral	65	17.3
Bilateral	54	14.4
Prolonged expiration	58	15.5
Hyperresonance to percussion
Unilateral and/or bilateral	36	9.6
Bilateral	33	8.8
Any of the five chest signs	145	38.7

Notes:

a n = 355, missing = 20

b missing = 3

c missing = 4

d missing = 4

e missing = 4

f missing = 5

g missing = 6

Abbreviations: GOLD, Global Initiative for Chronic Obstructive Lung Disease; COPD, chronic obstructive pulmonary disease; CCQ, clinical COPD questionnaire.

Figure 1 Frequency of heavy smoking, shortness of breath, and chest findings by level of lung function in 375 patients aged ≥40 years diagnosed with asthma or chronic obstructive pulmonary disease (COPD) in primary care. The patients were in a stable phase of illness.

Diagnostic values

The probability of COPD increased by the number of pack-years the patients had been smoking (Table 3). With more than 40 pack-years, the LR was 4.1. To have ever smoked had the highest sensitivity of all findings (0.83), but the specificity was low (0.35). Among the respiratory symptoms, shortness of breath doing physical activities, occurring a great many times the previous week, had the highest LR, whereas cough and phlegm were not significant predictors of COPD. The strongest COPD predictors were found among the chest signs, and hyperresonance to percussion had the highest LR (9.5) and specificity (0.98) (Table 3). There was no statistically significant association between crackles and COPD.

Table 3 Values of smoking habit, respiratory symptoms, and chest signs in predicting COPD (postbronchodilator FEV₁/FVC < 0.7) in 375 patients diagnosed with asthma or COPD

	Sensitivity	Specificity	LR	CI	PPV (%)
Smoking
>0 pack-years	0.87	0.34	1.3	1.2–1.5	46.6
≥20 pack-years	0.61	0.76	2.5	1.9–3.3	62.6
≥40 pack-years	0.19	0.95	4.1	2.0–8.2	73.0
Respiratory symptoms during the previous week
Short of breath at rest, several times or more	0.13	0.90	1.3	0.8–2.4	46.3
Short of breath doing physical activities, several times or more	0.63	0.57	1.4	1.2–1.8	48.7
Short of breath doing physical activities, many times or more	0.42	0.71	1.4	1.1–1.9	48.0
Short of breath doing physical activities, a great many times or more	0.27	0.87	2.0	1.3–3.0	56.5
Cough, several times or more	0.40	0.60	1.0	0.8–1.3	39.6
Phlegm, several times or more	0.36	0.63	1.0	0.7–1.3	38.8
Chest signs
Wheezes/rhonchi	0.26	0.89	2.3	1.5–3.7	60.3
Crackles	0.09	0.90	0.9	0.5–1.8	37.8
Diminished breath sounds	0.34	0.93	5.1	3.0–8.7	76.9
Prolonged expiration	0.29	0.93	4.3	2.5–7.5	74.1
Hyperresonance to percussion	0.21	0.98	9.5	3.7–23.7	86.1
Any of the five chest signs	0.58	0.74	2.3	1.8–3.0	60.0

Note: The overall prevalence of COPD was 39.7%.

Abbreviations: COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; LR, likelihood ratio; CI, confidence interval; PPV, positive predictive value.

When the predictors were evaluated against severe COPD, sensitivity was generally higher and specificity lower, whereas the LRs were only slightly changed (Table 4).

Table 4 Diagnostic values of smoking habit, respiratory symptoms, and chest signs in predicting severe COPD (postbronchodilator FEV₁/FVC < 0.7 and FEV₁% predicted <50) in 375 patients diagnosed with asthma or COPD

	Sensitivity	Specificity	LR	CI	PPV (%)
Smoking
>0 pack-years	0.96	0.28	1.3	1.2–1.5	15.1
≥20 pack-years	0.72	0.65	2.1	1.6–2.7	22.3
≥40 pack-years	0.30	0.92	3.9	2.2–7.1	35.1
Respiratory symptoms during the previous week
Short of breath at rest, several times or more	0.23	0.91	2.4	1.3–4.6	24.4
Short of breath doing physical activities, several times or more	0.89	0.54	1.9	1.6–2.2	20.4
Short of breath doing physical activities, many times or more	0.64	0.70	2.1	1.6–2.8	22.0
Short of breath doing physical activities, a great many times or more	0.41	0.84	2.6	1.7–4.1	21.6
Cough, several times or more	0.52	0.61	1.6	0.9–2.9	15.4
Phlegm, several times or more	0.46	0.65	1.3	0.9–1.9	14.9
Chest findings
Wheezes/rhonchi	0.36	0.86	2.7	1.6–4.1	25.4
Crackles	0.09	0.90	0.9	0.3–2.5	10.8
Diminished breath sounds	0.57	0.88	4.7	3.2–6.9	38.5
Prolonged expiration	0.43	0.88	3.7	2.3–5.7	32.8
Hyperresonance to percussion	0.39	0.94	6.7	3.8–12.0	47.2
Any of the five chest signs	0.82	0.67	2.5	2.0–3.1	24.8

Note: The overall prevalence of severe COPD was 11.7%.

Abbreviations: COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; LR, likelihood ratio; CI, confidence interval (for LR); PPV, positive predictive value.

Multivariate analysis

In the multivariate regression models, any degree of COPD could be independently predicted by pack-years but not by shortness of breath, whereas the opposite was the case for severe COPD (Table 5). Age and chest signs were significant predictors for both outcomes. Among the chest findings, diminished breath sounds and hyperresonance to percussion were the two strongest independent predictors.

Table 5 Independent predictive values of smoking, respiratory symptoms, and chest signs for COPD (FEV₁/FVC < 0.7) and severe COPD (FEV₁/FVC < 0.7 and FEV₁% predicted <50), as evaluated by multivariate logistic regression in 351 patients diagnosed with asthma or COPD

	COPD		Severe COPD
	Odds ratio	CI	Odds ratio	CI
Male sex	1.8	1.1–3.2	NS
Age	2.7	1.6–4.7	2.4	1.1–5.1
Pack years
≥20–40	4.9	2.7–8.8	NS
≥40	3.3	1.3–8.3	NS
Short of breath doing physical activities the previous week
Several times	NS		1.7	1.1–2.5
Many times	NS		1.5	1.1–2.0
A great many times	NS		8.4	2.7–25.8
Chest signs
Wheezes/rhonchi	2.3	1.1–4.8	NS
Diminished breath sounds	5.0	2.2–11.3	4.4	2.0–9.8
Hyperresonance to percussion	6.7	2.0–22.0	5.3	2.0–13.7

Abbreviations: COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; CI, confidence interval; NS, not significant.

ROC-curve analyses displaying diagnostic values for COPD of dyspnea score (CCQ score for shortness of breath during physical activities), pack-years, and chest-finding score showed added diagnostic value when the three scores were used together (Figure 2). The added score predicted severe COPD more strongly (area under the curve [AUC] = 0.88) than it predicted COPD of any degree of severity (AUC = 0.75). The AUC obtained with all three scores in the model was higher than the upper limit of the 95% confidence interval of the AUC when only pack-years and dyspnea score were included.

Figure 2 Receiver operating-characteristic curves showing predictive value of three different scores in predicting COPD (FEV₁/FVC < 0.7) and severe COPD (FEV₁/FVC < 0.7 and FEV₁% predicted <50): dyspnea score (short of breath doing physical activities in the clinical COPD questionnaire), summing up of dyspnea score and pack-years (0–10, 1; 10–20, 2; 20–40, 3; ≥40, 4), and summing up of dyspnea score, pack-years, and chest-finding score (addition of wheezes, 1; diminished breath sound, 2; hyperresonance to percussion, 3).

Abbreviations: COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; CI, confidence interval; AUC, area under the curve.

Sensitivity analyses

COPD was somewhat more prevalent and chest signs less frequently recorded in the four practices where auscultation was done before spirometry, compared to the other three practices (Table 6). The less frequent recording of abnormal chest findings was associated with somewhat lower sensitivity and considerably higher specificity and LR. This was the case whether the diagnostic value of any chest finding was evaluated against prebronchodilator or postbronchodilator spirometry.

Table 6 Sensitivity analysis comparing lung function, the prevalence of any chest sign, and the sensitivity, specificity, and likelihood ratio of any chest sign for COPD in practices where patients were examined before spirometry and after spirometry

	n	Any chest sign, n (%)		COPD (FEV1/FVC < 0.7), n (%)		Sensitivity	Specificity	Likelihood ratio (95% CI)
Patients examined before spirometry (4 GP offices)
Evaluated against prebronchodilator spirometry	211	72	34.1a	98	46.4b	53.1	82.3	3.0 (1.9–4.7)
Evaluated against postbronchodilator spirometry	211	72	34.1	94	44.5c	56.7	83.8	3.5 (2.2–5.4)
Patients examined after spirometry (3 GP offices)	164	73	44.5	55	33.5	61.8	64.2	1.7 (1.2–2.4)

Notes:

a The difference between the subgroups examined before and after spirometry was statistically significant, P = 0.04

b the difference between the subgroups examined before and after spirometry was statistically significant, P = 0.01

c the difference between the subgroups examined before and after spirometry was statistically significant, P = 0.03.

Abbreviations: COPD, chronic obstructive pulmonary disease; FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; CI, confidence interval; GP, General Practitioner.

Discussion

Main findings

Presence of prolonged expiration, wheezes, hyperresonance to percussion, and diminished breath sounds by physical chest examination significantly increased the probability of bronchial obstruction in our study sample. Hyperresonance to percussion and diminished breath sounds got higher like-lihood ratios than did heavy smoking and any respiratory symptoms. These two chest signs, and also wheezes, were found with similar frequency in the patients with moderate COPD (GOLD II), as were ≥40 pack-years and frequent dyspnea on physical activities. The three chest signs gave significant diagnostic information when added to dyspnea and pack-years, as shown by both logistic regression and ROC-curve analysis. A model including pack-years, shortness of breath, and chest signs had good test characteristics by ROC-curve analysis in predicting COPD and even better in predicting severe COPD. The findings indicate that abnormal chest findings, as well as a history of shortness of breath and smoking, are cues that should prompt spirometry in patients 40 years or older with no established diagnosis of COPD.

Strengths and weaknesses

Our study is among the largest studies carried out to evaluate chest findings as signs of bronchial obstruction. For comparison of our results with previous studies, it was an advantage to evaluate against both “any” COPD and severe COPD, since reductions in lung function somewhere in between our two cutoff levels have usually been used as outcomes in previous studies. Although the sensitivity of the chest findings was higher and specificity lower when using severe obstruction as the reference standard compared to when FEV₁/FVC < 0.7 was used, we observed that the LR showed little variation (Tables 3 and 4), as can be expected when both the numerator and the denominator in the fraction (sensitivity/1 – specificity) decreases. This supports comparisons with previous studies.

A main concern in studies like this is the selection of patients studied and whether the results are applicable in other settings. Like in most previous studies, our study sample consisted of patients with known or possible obstructive lung disease. The patients had at least once during the preceding 5 years been labeled with a diagnosis of asthma or COPD, but we do not know to what degree the registered diagnoses were based on established criteria.¹² Overrepresentation of severe cases among the COPD patients and overrepresentation of asthma among those with normal spirometry have most probably led to increased sensitivity and decreased specificity of the chest signs. The LRs, however, were probably less affected. Ideally, we should have recruited unselected patients above 40 years of age. Only a few studies have focused on adults without known bronchial obstruction.^11,17,18 There is a tendency of decreasing frequency of chest signs in COPD patients (sensitivity) with decreasing prevalence of COPD in the study sample. The lower sensitivity in such samples is usually counterweighted by a higher specificity,¹¹ resulting in the LR being less affected.¹⁷ This makes it likely that our results are applicable also in patient populations with a lower prevalence of COPD.

The computerized form the GPs had to fill in during the consultation led to complete recording of chest findings. Since all patients had previously been labeled with a diagnosis of asthma or COPD by a GP, one could expect that the chest examination was carried out with similar attention in all patients. However, chest findings only made up a small part of the registrations, and the main topic of the study was exacerbations of asthma and COPD. With this focus, the GPs have probably been less prone to “adjust” their recordings to the severity of the patient’s disease than if evaluation of chest examination had been the aim. A rigorous design with the GPs blinded for all clinical information was probably not of fundamental importance. At the three GP practices where chest examination was carried out after the spirometry, the GPs could in theory check the spirogram before examining the patient and possibly expect more chest findings in patients with bronchial obstruction and fewer findings when the FEV₁/FVC was above 0.7. From the results, this does not appear to have occurred. More findings were recorded in patients without obstruction, and the lowest specificity and LRs of chest findings were found in the practices where the patients were examined after spirometry.

This inconsistency suggests sources of flaw that cannot be addressed by blinding the observing doctor. Previous studies have demonstrated considerable interobserver variation when patients have been examined by more than one doctor.¹⁹ This has particularly been the case for hyperresonance to percussion and diminished breath sounds.¹⁹ Percussion of the chest is somewhat demanding, and the skills needed to elicit a hyperresonant sound may vary between doctors.²⁰ To differentiate between normal and diminished breath sounds, proper instructions to the patient, clinical experience, and attentive listening are needed. The terms used for abnormal lung sound vary between clinicians.^21,22 Improved skills among the GPs in examining the chest and more standardized use of terms when describing the findings are likely to improve the diagnostic value of the findings.

The most important strength of the study is that we evaluated chest signs together with smoking history and shortness of breath, the symptoms regarded as the best cues to an early diagnosis of COPD. We found chest signs to be independent predictors that add to these established cues, and we see no good reason why these strong findings should not be applicable also in unselected adults, at least to some significant degree.

Comparisons with previous studies

Hyperresonance to percussion

Similar sensitivity and specificity of hyperresonance to percussion have been found in previous studies when evaluated against bronchial obstruction among adults with a possible lung disease¹¹ or a history of smoking.⁶ Our study confirms that hyperresonance to percussion is a strong predictor, with an LR above 5.

Diminished breath sounds

Diminished breath sounds have also previously been shown to predict bronchial obstruction, with LRs between 2 and 6.¹¹ In a recent study from primary care of patients with persistent cough, diminished breath sounds significantly predicted FEV₁/FVC < 0.7 in univariate analysis (sensitivity 0.16 and specificity 0.91), but not in multivariate analysis.¹⁸ The considerable variation in diagnostic properties of this variable probably reflects that it is particularly susceptible to interobserver variability.

Wheezes/rhonchi and crackles

Associations between wheezes/rhonchi and bronchial obstruction have been demonstrated in several studies,^{9,10,17,18,23,24} and LRs between 2 and 3, as in the present study, have been found, also among patients without known bronchial obstruction.^11,17,18 Crackles were not a significant predictor in our study, in contrast to what has been found in previous studies.^7,11

Smoking and respiratory symptoms

Smoking history, shortness of breath, and cough with phlegm are well-known predictors of COPD.^17,24–27 In a recent study of adults aged 40 years or more with a COPD prevalence of only 9.6%, all these variables were significant predictors of COPD.²⁸ The ROC-curve analysis of a diagnostic model including age, smoking status, and breathlessness obtained an AUC of 0.77.²⁸ This is close to the AUC of 0.80 for pack-years and dyspnea when evaluated against severe COPD in our study.

Implications for practice

Based on our findings and supported by previous studies, we suggest reinstating chest findings as cues to the early diagnosis of COPD. At present, their relevance is not reflected in established guidelines. Smoking and respiratory symptoms, but not chest findings, are listed as information that should lead to spirometry in a search for COPD. GOLD argues that “Physical signs of airflow limitation are usually not present until significant impairment of lung function has occurred, and their detection has a relatively low sensitivity and specificity.”¹ In the National Institute for Health and Care Excellence guidelines, it is stated that the diagnosis of COPD “is suspected on the basis of symptoms and signs and supported by spirometry.” Physical chest findings are not listed among the clinical information that should raise suspicion for COPD, and are considered less predictive than symptoms in COPD assessment.²⁹ A similar understanding of the value of chest signs in the early diagnosis of COPD is presented by Rennard.³⁰

The predictive value of chest signs for COPD is only one reason chest findings should be reinstated in early diagnosis. In practice, chest examination is carried out in all kinds of patients, such as those with hypertension, heart disease, and respiratory tract infections. The examination is done quickly and carried out frequently, also during busy consultations, and it has high standing (face value) among patients. To elicit a thorough history on smoking and respiratory symptoms, which of course often should be done, takes longer time and is probably less frequently carried out. COPD questionnaires are not easily implemented in a busy practice, and they have not been evaluated as elements of ordinary consultations. So far, we do not know whether the diagnostic properties of such questionnaires in disclosing mild-to-moderate COPD are better than those of chest signs.

Acknowledgments

The authors thank the participating patients and Nordbyen legesenter in Tromsø, Allmed legesenter in Hammerfest, Alta Helsesenter, Skedsmokorset legesenter, Langbølgen legesenter in Oslo, and Gransdalen legesenter in Oslo for taking part in the study.

Disclosure

The authors report no conflicts of interest in this work.