Novel Approaches to Treating Relapsed and Refractory Multiple Myeloma with a Focus on Recent Approvals of Belantamab Mafodotin and Selinexor

Abstract

Though survival outcomes in multiple myeloma patients have improved drastically over the past few decades, there still remains an ongoing need for effective and tolerable treatment options in the relapsed and refractory space. Encouragingly, there have been three recent FDA approvals for triple-class refractory multiple myeloma, and there is promising ongoing development of additional agents with varying novel mechanisms of action. Here, we will review the most recent data on both belantamab mafodotin, an antibody drug conjugate (ADC) targeting BCMA, and selinexor, a first-in-class selective inhibitor of XPO1, as well as touch on some of the recently published data for other immunotherapies in development, namely bispecific T cell engagers, ADCs, and CAR-T cell therapies.

Keywords:

• belantamab mafodotin
• belamaf
• selinexor
• relapsed/refractory myeloma
• myeloma

Disclosure

Dr Kenneth C Anderson reports personal fees from Pfizer, Amgen, AstraZeneca, Janssen, Precision Biosciences, Mana, Windmill, Raqia, C4 Therapeutics, and oncopep, during the conduct of the study. Dr Sagar Lonial reports grants and/or personal fees from Takeda, Janssen, BMS, Celgene, GSK, AbbVie, Bluebird, Novartis, and Pfizer; personal fees from and board of directors for TG Therapeutics, during the conduct of the study. The authors report no other conflicts of interest in this work.