The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes

Abstract:

Circadian clocks regulate cellular to organic and individual behavior levels of all organisms. Almost all cells in animals have self-sustained clocks entrained by environmental signals. Recent progress in genetic research has included identification of clock genes whose disruption causes metabolic abnormalities such as diabetes, obesity, and hyperlipidemia. Here we review recent advances in research on circadian disruption, shift work, altered eating behaviors, and disrupted sleep-wake cycles, with reference to management of type 2 diabetes.

Keywords::

• diabetes
• clock gene
• shift work
• eating behavior
• sleep loss

Disclosure

The authors have no conflicts of interest to declare.