The therapeutic efficacy of propranolol in children with recurrent primary epistaxis

Bojko Bjelakovic1 Clinic of Pediatrics, Clinical Center, Nis, Serbia;2 Faculty of Medicine, University of Nis, Nis, SerbiaCorrespondence[email protected]

Mila Bojanovic2 Faculty of Medicine, University of Nis, Nis, Serbia;3 Clinic of Otorhinolaryngology, Clinical Center, Nis, Serbia

Stevo Lukic2 Faculty of Medicine, University of Nis, Nis, Serbia;4 Clinic of Neurology, Clinical Center, Nis, Serbia

Ljiljana Saranac1 Clinic of Pediatrics, Clinical Center, Nis, Serbia;2 Faculty of Medicine, University of Nis, Nis, Serbia

Vladislav Vukomanovic5 Mother and Child Health Institute, “Dr Vukan Cupic”, Belgrade, Serbia;6 Faculty of Medicine University of Belgrade, Serbia

Sergej Prijic5 Mother and Child Health Institute, “Dr Vukan Cupic”, Belgrade, Serbia

Nikola Zivkovic7 Institute of Pathology, Faculty of Medicine, University of Nis, Nis, Serbia

Dusica Randjelovic1 Clinic of Pediatrics, Clinical Center, Nis, Serbia

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Abstract

We hypothesized that some characteristics of beta-blockers, including negative inotropic, peripheral vasoconstrictor, and antiangiogenic effects, might be potentially useful in treating children with epistaxis. From June 2010 to March 2012, a total of seven children with recurrent primary epistaxis resistant to conventional management were observed at our institution. An overall effectiveness of propranolol was noted in all seven children when given a dose of 1.5–2 mg/kg/day (divided into three doses) as a second line therapy for terminating epistaxis. Based on our first experience, we believe that propranolol could be a favorable treatment option for patients with primary epistaxis.

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Acknowledgments

This work has been supported by the Ministry of Science and Technology of the Republic of Serbia by grant No 175092.

Disclosure

The authors report no conflicts of interest in this work.

The therapeutic efficacy of propranolol in children with recurrent primary epistaxis

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The therapeutic efficacy of propranolol in children with recurrent primary epistaxis

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