Influences of Propofol, Ciprofol and Remimazolam on Dreaming During Anesthesia for Gastrointestinal Endoscopy: A Randomized Double-Blind Parallel-Design Trial

Abstract

Purpose

To compare the influences of propofol, ciprofol and remimazolam on dreaming during painless gastrointestinal endoscopy.

Methods

This study was a single-center, prospective, parallel-design, double-blind, randomized clinical trial. Between May 2023 and October 2023, patients undergoing elective painless gastrointestinal endoscopy were recruited and randomly allocated into one of the three groups. Demographic data, intraoperative information, incidence of dreaming, insufficient anesthesia and intraoperative awareness, type of dream, patient satisfaction score, adverse events, and improvement of sleep quality were collected.

Results

The difference in incidence of dreaming among the three groups was not significant (33.33% vs 48.33% vs 41.67%, p=0.061). The number of patients with intraoperative hypotension in the propofol group was larger than that of the remimazolam group (32 vs 12, p=0.001). However, the cases of intraoperative hypotension between propofol group and ciprofol group or ciprofol group and remimazolam group were comparable (32 vs 22, p=0.122; 22 vs 12, p=0.064). The percentage of insufficient anesthesia between propofol group and remimazolam group was significant (13.33% vs 1.67%, p=0.001), while no statistical difference was detected between propofol group and remimazolam group or ciprofol group and remimazolam group (13.33% vs 5.00%, p=0.025; 5.00% vs 1.67%, p=0.150). The ability of propofol to improve sleep quality at 1st post-examination day was significantly better than that of remimazolam (86.21% vs 72.88%, p=0.015), while it was not significant between propofol group and ciprofol group or ciprofol group and remimazolam group (86.21% vs 80.36%, p=0.236; 72.88% vs. 72.88%, p=0.181). Incidence of intraoperative awareness, intraoperative hypoxia, type of dream, satisfaction score, adverse events during recovery, and sleep improvement on the 7th post-examination day was not significant among the groups.

Conclusion

Anesthesia with propofol, ciprofol and remimazolam, respectively, for gastrointestinal endoscopy did not induce statistical difference in the incidence of dreaming, despite that all of them are more likely to induce pleasant dreams.

Keywords:

• propofol
• ciprofol
• remimazolam
• endoscopic sedation
• dreaming

Data Sharing Statement

The database of this study can be obtained by contacting the corresponding authors.

Ethics Approval and Consent to Participate

This study was approved by the Ethics Committee of Deyang People’s Hospital on April 20, 2023, with a registration number 2023-04-031-K01. Trial registration was conducted in the Chinese Clinical Trial Registry on May 18, 2023 (www.chictr.org.cn; registration number: ChiCTR2300072987). All the subjects provided their written informed consent. The study protocol was designed in line with the CONSORT guidelines and performed in accordance with the Declaration of Helsinki.

Acknowledgments

We appreciate the support from the Endoscopy Center and Department of Digestive System in Deyang People’s Hospital.

Author Contributions

All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.

Disclosure

The authors declare that there are no existing or potential conflicts of interest in this work.

Additional information

Funding

This study was supported by “Xinglin Scholar” Hospital Project of Chengdu University of Traditional Chinese Medicine (YYZX2022077, Leqiang Xia), and Scientific and technological innovation 2030 – major project of Brain Science and Brain-Like Intelligence Technology (2021ZD0202804, Lize Xiong).