The Association Between Hemoglobin HbA1c with Serum Inorganic Phosphate in Children with Type 1 Diabetes

Abstract

Background

Diabetes mellitus is one of the most common chronic metabolic diseases in children and adolescents, which changes the cellular metabolism. Phosphorus is an essential element for metabolism. Early in the progression of diabetes, a paradoxical metabolic imbalance in inorganic phosphate (Pi) occurs that may lead to reduced high energy phosphate and tissue hypoxia. While low and high uncontrolled blood sugars can be easily recognized by clinical symptoms, low and high plasma inorganic phosphate remain unrecognizable. Therefore, we aimed to assess the association between hemoglobin A1c (HbA1c) with serum inorganic phosphate in children with type 1 diabetes.

Materials and Methods

This cross-sectional study was conducted on 102 patients selected from a pediatric ward in 17th Shahrivar hospital in Rasht, North of Iran. Clinical data including age, sex, height, weight, BMI, duration of diabetes, the level of HbA1c, and phosphorus were gathered. The level of HbA1c was adjusted by age in the final analysis.

Results

The mean age of samples was 9.98±3.91 years old and 46 participants (45.1%) were male. It was found that HbA1c had a reversed and significant relationship with BMI (r=−0.215 and P=0.03), but there was no correlation between phosphate, age, height and weight, duration of diabetes mellitus, or rate of insulin consumption with HbA1c (P>0.05).

Conclusion

The finding showed that HbA1c had a reversed relationship with BMI but there was no correlation between phosphate and HbA1c.

Keywords:

• phosphate
• diabetes mellitus
• child
• glycated hemoglobin A
• Iran

Acknowledgments

This investigation was based on the thesis submitted by the second author (Amir Reza Nemati) to the Guilan University of Medical Sciences. This study was done with financial support provided by Vice Chancellor of Research, Guilan University of Medical Sciences.

Disclosure

The authors report no conflicts of interest in this work.