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Abstract
Background
Diabetes is one of the most prevalent noncommunicable diseases worldwide. Children’s lipid accumulation product (CLAP) is a novel indicator to show children’s lipid accumulation and is effectively associated with metabolic syndrome among children and adolescents. The aim of the present study was to explore an association between CLAP and impaired fasting glucose (IFG) in Chinese children and adolescents.
Methods
A total of 683 children and adolescents aged 8–15 years were recruited using the stratified cluster sampling method in this cross-sectional study and were measured for body height, weight, waist circumference (WC), abdominal skinfold thickness (AST), triglycerides (TG), fasting plasma glucose, dietary behaviors and physical activities. A logistic regression model and receiver operating characteristic (ROC) curve were used to compare the effects of CLAP for predicting IFG.
Results
The prevalence of IFG in children and adolescents was 13.8%: 16.9% in boys and 10.1% in girls (P<0.05). The CLAP, height, weight, WC, AST, waist-to-height ratio (WHtR), and TG among boys with IFG were significantly higher than those among boys without IFG (P<0.05). The area under the ROC curve of CLAP for predicting IFG (0.637 (0.562–0.712)) was higher than those of WC, WHtR, AST, and TG. The cutoff point of P75 CLAP was the optimal value to predict IFG among boys, and the OR (95% CI) was 2.48 (1.40–4.42) and area under the ROC curve was 0.595 (0.513–0.676).
Conclusion
The CLAP was a novel indicator associated with IFG in Chinese boys, and it performed better than WC, WHtR, AST and TG.
Acknowledgments
This project was supported by grants from the National Natural Science Foundation of China (No. 81502823), Sciences Foundation of Ministry of Education of China (No. 15YJAZH085), Outstanding Young Talent Key program of College and University in Anhui Province (No. gxyqZD2017063) and University Natural Science Foundation of Anhui Province (No. KJ2019A0298). The authors would like to thank the students who participated in the current study and thank Weige Jiang and Yu Liu for assisting in recruiting students.
Disclosure
Yongting Yuan and Hong Xie are co-first authors. All authors gave final approval of the submitted manuscript versions and declare no conflicts of interest in this work.