Fasting Plasma Glucose and Glycated Hemoglobin Levels as Risk Factors for the Development of Hypertension: A Retrospective Cohort Study

Abstract

Introduction

Hypertension (HTN) is a significant risk factor for cardiovascular disease. Identifying new risk factors for hypertension is crucial. This study aims to determine the predictive value of fasting plasma glucose (FPG) and glycated hemoglobin (HbA1c) in the development of hypertension.

Methods

In this study, we examined 16,026 individuals without diabetes and other cardiovascular risk factors who were underwent annual screening at the People’s Hospital of Yuxi, Yunnan, China from 2013 to 2016. The participants were divided into two groups: normoglycemic and prediabetic. Normoglycemia was defined as having an HbA1c level of less than 5.7% and an FPG level of less than 5.6 mmol/ L. Prediabetes was defined according to the ADA criteria, which includes having an HbA1c level between 5.7% and 6.5%, or an impaired fasting glucose level between 5.6 mmol/L and 7.0 mmol/L. The participants were further divided into four subgroups based on their FPG and HbA1c levels: normoglycemia, impaired HbA1c only, FPG only, and both parameters impaired.

Results

The cohort study was conducted on 16,026 participants from Yunnan, China, consisting of 60.6% males and 39.4% females, with a mean age of 44.6 ± 12.5 years. The study revealed that prediabetes was independently associated with an increased risk for HTN (OR 1.53, 95% CI 1.41~1.67, P < 0.001). The analysis of different subgroups of HbA1c and FPG showed that FPG was a better predictor of HTN than HbA1c, regardless of the group.

Conclusion

FPG and HbA1c were significantly associated with the future development of HTN in individuals with prediabetes.

Keywords:

• glycated hemoglobin
• glucose
• hypertension

Disclosure

The authors report no conflicts of interest in this work.

Additional information

Funding

We gratefully acknowledge support from the Regional Fund Project of the National Natural Science Foundation (Serial number: 82160402), the Training plan for medical leading talents of Yunnan Health Commission (Serial number: L-2019022).