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Abstract
Diabetes is the leading cause of chronic kidney disease, and the prevalence of both diseases is rising worldwide. Treatment of type 2 diabetes is difficult in patients with chronic kidney disease because most oral antidiabetic agents are affected by renal function and their use may be contraindicated in this patient population. Antidiabetic agents that can be used in patients with type 2 diabetes and declining renal function are needed. Incretin-based therapies, such as dipeptidyl peptidase-4 inhibitors, are a recent therapeutic class of glucose-lowering agents that may offer an effective treatment option in patients with chronic kidney disease. Within the dipeptidyl peptidase-4 class, linagliptin has a unique profile with a primarily nonrenal route of elimination, requiring no dose adjustment in patients with chronic kidney disease. This communication summarizes the findings of a 1-year, randomized, double-blind, placebo-controlled study demonstrating the favorable safety and efficacy profile of linagliptin in patients with type 2 diabetes and severe renal impairment.
Disclosure
The author was fully responsible for all content and editorial decisions, was involved at all stages of manuscript development, and approved the final version of the review reflecting the author’s interpretation and conclusions. Boehringer Ingelheim was given the opportunity to check the data used in the manuscript for factual accuracy only. Medical writing assistance, supported financially by Boehringer Ingelheim, was provided by Michael P Bennett and Linda Merkel of Envision Scientific Solutions during preparation of this paper.