Comparative Evaluation of Two SD-OCT Macular Parameters (GCC, GCL) and RNFL in Chiasmal Compression

Abstract

Purpose

To evaluate the relationship between different macular thickness parameters analyzed by SD-OCT and the central visual field (VF) evaluated with automated kinetic perimetry in a cohort of patients with pituitary tumors.

Methods

Data from patients with pituitary adenoma treated at Reims University Hospital between October 1st, 2017, and May 31st, 2018 were collected. All patients underwent an automated kinetic perimetry and a SD-OCT to map the ganglion cell complex (GCC), the ganglion cell layer (GCL) thickness and the retinal nerve fiber layer (RNFL) using devices from two different manufacturers. Univariate and multivariate analysis were used to evaluate the correlation between the area of central VF in square degrees (deg2) and the SD-OCT parameters (μm).

Results

Eighty-eight eyes were included in the analysis. All the thickness parameters measured in SD-OCT decreased with the visual field alteration. The best correlation was observed between superior thickness parameters (GCC, GCL) and the inferior central visual field. The most pertinent predictive factors for visual field loss were the inferior central GCL and the nasal RNFL (both AUC=0.775) with a sensitivity respectively of 86% and 70%.

Conclusion

This study suggests that both GCC, GCL thickness parameters could be reliable predictors of central visual field impairment in patients with pituitary tumors. There was no significative difference between both devices.

Keywords:

• optic chiasma
• visual field
• ganglion cell complex
• ganglion cell layers
• compressive optic neuropathy
• optic coherence tomography
• retinal nerve fiber layer
• pituitary tumors
• pituitary adenomas

Statement of Ethics

This was performed in accordance with the ethical standard for the Declaration of Helsinki. Database was built in accordance with the reference methodology MR003 of the Commission Nationale de l’Informatique et des Libertés (n°2016198, 12th December 2016). Patients were informed that the study was being carried out via the hospital’s registry of ongoing studies, and non-opposition forms were sent to all patients included, explaining that data will be collected and that they may oppose. In absence of opposition within the time set limit, data were collected and anonymized prior to analysis.

According to the French Public Health Code, this research also did not need require an ethical committee.²⁶

Disclosure

Prof. Dr. Carl Arndt reports non-financial support from Metrovision, grants from Heidelberg Engineering, during the conduct of the study. The authors have no other conflicts of interest to declare.

Additional information

Funding

The authors do not have any funding source relative to this research to declare.