Abstract
Purpose
To explore the distribution of pathogenic bacteria in patients with intra-abdominal infection, to clarify the independent factors that affect the prognosis of patients with intra-abdominal infection and its evaluation value for prognosis.
Patients and Methods
The pathogens, underlying diseases, and related clinical data of patients with intra-abdominal infection from January 2012 to December 2019 in our hospital were retrospectively collected and the APACHE II score was calculated. The patients were divided into survival group and death group according to the prognosis, and the index between the two groups was compared. Spearman correlation analysis was used to evaluate the correlation between each index and prognosis, multivariate logistic regression analysis was used to screen the independent prognostic factors.
Results
Spearman correlation analysis showed that ALB level was negatively correlated with prognosis, age and APACHE II score were positively correlated with prognosis. Logistic regression analysis showed that age, ALB level, and APACHE II score were independent prognostic factors. The formula of age combined ALB level and APACHE II score was Y = X1-3.6X2 + 6.5X3 (X1 was the age, X2 was the ALB level and X3 was the APACHE II score), Y was positively correlated with poor prognosis, and the optimal cutoff value was Y = 40.96.
Conclusion
Age, ALB level, and APACHE II score are independent factors that influencing the prognosis of patients with intra-abdominal infection, and the combination of age, ALB level, and APACHE II score can better assess the prognosis of patients with intra-abdominal infection.
Acknowledgments
This project was supported by Beijing Postdoctoral Research Foundation (2020-ZZ-008), Returned overseas students from Anhui Province in 2020 Innovation and Entrepreneurship Support Plan Project (2020LCX016), University Natural Science Research Project of Anhui Province (KJ2020A0172), and Cultivate Funding of the National Natural Science Foundation of China (2016KJ12).
Ethics Approval and Consent to Participate
This observational study was conducted according to the terms and regulations of the local institutional review boards (Anhui Medical University, Hefei, Anhui, agreement; AHMU 202211). According to Chinese Law, no informed consent was required since this observational study did not modify the physician’s treatment decisions.
Author Contributions
All authors made a significant contribution to the work reported, whether that is in the conception, study design, execution, acquisition of data, analysis and interpretation, or in all these areas; took part in drafting, revising or critically reviewing the article; gave final approval of the version to be published; have agreed on the journal to which the article has been submitted; and agree to be accountable for all aspects of the work.
Disclosure
The authors declare that they have no competing interests.